ArticleEvolution; international journal of organic evolution2021
Macroevolutionary foundations of a recently evolved innate immune defense.
Article in Evolution; international journal of organic evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations.bioRxiv : the preprint server for biology · 2026Article
- Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes.Molecular biology and evolution · 2026Article
- Changes in gene regulation are associated with the evolution of resistance to a novel parasite.Frontiers in immunology · 2026Article
- Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater.Evolution letters · 2025Article
- The Dominance of Coinfecting Parasites' Indirect Genetic Effects on Host Traits.The American naturalist · 2024Article
- The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species.Evolutionary applications · 2024Article
- Evolutionary gain and loss of a pathological immune response to parasitism.Science (New York, N.Y.) · 2022Article
- Population-level variation in parasite resistance due to differences in immune initiation and rate of response.Evolution letters · 2022Article
- Review
- Macroevolutionary foundations of a recently evolved innate immune defense.Evolution; international journal of organic evolution · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Antagonistic interactions between hosts and parasites may drive the evolution of novel host defenses, or new parasite strategies. Host immunity is therefore one of the fastest evolving traits. But where do the novel immune traits come from? Here, we test for phylogenetic conservation in a rapidly evolving immune trait-peritoneal fibrosis. Peritoneal fibrosis is a costly defense against a specialist tapeworm, Schistocephalus solidus (Cestoda), expressed in some freshwater populations of threespine stickleback fish (Gasterosteus aculeatus, Perciformes). We asked whether stickleback fibrosis is a derived species-specific trait or an ancestral immune response that was widely distributed across ray-finned fish (Actinopterygii) only to be employed by threespine stickleback against the specialist parasite. We combined literature review on peritoneal fibrosis with a comparative experiment using either parasite-specific, or nonspecific, immune challenge in deliberately selected species across fish tree of life. We show that ray-finned fish are broadly, but not universally, able to induce peritoneal fibrosis when challenged with a generic stimulus (Alum adjuvant). The experimental species were, however, largely indifferent to the tapeworm antigen homogenate. Peritoneal fibrosis, thus, appears to be a common and deeply conserved fish immune response that was co-opted by stickleback to adapt to a new selective challenge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.