Evidence map›Paper›PMID 34347266›Full record

ArticleNeurochemical research2021

Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.

Zhe Zhong, Weijie Chen, Huan Gao, Ningning Che, Min Xu, Lanqing Yang, Yingfang Zhang, Min Ye

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 62 citations in OpenAlex.

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  11. The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  16. Microbiome-based therapeutics for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhe Zhong *Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Weijie Chen *Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Huan GaoDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Ningning CheDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Min XuDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Lanqing YangDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Yingfang ZhangDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China.
Min YeDepartment of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, No. 71, Hexi Street, Jianye District, 210019, Nanjing, Jiangsu, China. yemin197001@sina.com.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota is closely related to the Parkinson's disease (PD) pathogenesis. Additionally, aggregation of α-synuclein (α-syn) is central to PD pathogenesis. Here we identified the further mechanisms of gut microbiota in PD. A mouse model with PD was established via injection of MPTP. Normal or MPTP-induced PD like animals were treated with FMT from healthy normal mice. Pole test and traction test were performed to examine the effects of FMT on motor function of PD mice. Fecal SCFAs were assessed by gas chromatography-mass spectrometry. The α-syn level in the substantia nigra pars compacta (SN) of mice was measured using western blot. Dopaminergic neurons and microglial activation in the SN were analyzed by immunohistochemistry (IHC) and immunofluorescence (IF) staining. FMT alleviated physical impairment, decreased fecal SCFAs in a mouse model of PD. Additionally, FMT decreased the expression of α-syn, as well as inhibited the activation of microglia in the SN, and blocked the TLR4/PI3K/AKT/NF-κB signaling in the SN and striatum. FMT could protect mice against PD via suppressing α-syn expression and inactivating the TLR4/PI3K/AKT/NF-κB signaling.

Indexed as

alpha-SynucleinAnimalsFecal Microbiota TransplantationMaleMiceMice, Inbred C57BLNeuroprotectionNF-kappa BParkinsonian DisordersPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktToll-Like Receptor 4alpha-SynucleinNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTlr4 protein, mouseToll-Like Receptor 4Gut microbiotaParkinson's diseaseTLR4/PI3K/AKT/NF-κB signalingα-synuclein

Identifiers

PMID34347266
OpenAlexW3192603972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.