ArticleThe Journal of experimental medicine2021
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice.
Open access · greenAbstract readMulticenter Study
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Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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64citing papers in PubMed, 1 pooled it
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Systematic review of innate immune responses againstFrontiers in immunology · 2024Pooled it
- Early mucosal responses following a randomised controlled human inhaled infection with attenuated Mycobacterium bovis BCG.Nature communications · 2025Trial
- Review
- Eosinophil-associated matrix remodeling in a sterile granulomatous inflammation model: a temporal histopathological analysis.Histochemistry and cell biology · 2026Article
- Differential Regulation of Oxidative Burst by First Line Drugs Used Against Multi Drug-Resistant Tuberculosis in Naïve Human Innate Immune Cells.Antibiotics (Basel, Switzerland) · 2026Article
- Interstitial and recruited macrophages prevent tuberculosis relapse by limiting immune evasion.EMBO molecular medicine · 2026Article
- Hematological Profiles of Pulmonary Tuberculosis and Multi-Drug-Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North-Central Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
- Metabolically reprogrammed eosinophils impair T cell immunity and cause chronic skin infection.EMBO molecular medicine · 2026Article
- Peptide nanofibers and PAMP agonist combinations enhance pulmonary CD4Journal of nanobiotechnology · 2026Article
- Article
- Immune Dysregulation in HIV-TB Co-Infection: Role of Cytokines and T Cell Biomarkers-A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Clinical characteristics of peripheral blood eosinophilia in nontuberculous mycobacterial disease: a multicenter comparative retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Interaction effects of environmental factors with white blood cell profiles on mycobacterial pulmonary diseases: a case-control study.BMC infectious diseases · 2025Article
- Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice.Nature microbiology · 2025Article
- Mycobacterium tuberculosis biology, pathogenicity and interaction with the host.Nature reviews. Microbiology · 2025Review
- Article
- Pre-treatment blood cell counts and inflammatory markers predict the radiologic severity of post-tuberculosis lung disease.BMC infectious diseases · 2025Article
- Mast cells promote pathology and susceptibility in tuberculosis.bioRxiv : the preprint server for biology · 2025Article
- Single-cell RNA sequencing in tuberculosis: Application and future perspectives.Chinese medical journal · 2025Review
- An alveolus lung-on-a-chip model ofbioRxiv : the preprint server for biology · 2025Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 7 institutions in 7 countries.
Andrea C Bohrer *Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-4268-4853
Ehydel Castro *Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5900-248X
Zhidong Hu *Department of Scientific Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0001-8490-4389
Artur T L QueirozThe KAB group, Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador Brazil.ORCID 0000-0003-4908-9993
Claire E TochenyInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-5791-7560
Maike AssmannInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2669-9676
Shunsuke SakaiT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0344-9447
Christine NelsonT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-3879-9105
Paul J BakerInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-3642-2366
Hui MaDepartment of Scientific Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0003-3535-3802
Lin WangTuberculosis Center, Shanghai Emerging and Re-emerging Infectious Disease Institute, Fudan University, Shanghai, China.ORCID 0000-0001-5171-2663
Wen ZiluTuberculosis Center, Shanghai Emerging and Re-emerging Infectious Disease Institute, Fudan University, Shanghai, China.ORCID 0000-0001-6811-7721
Elsa du BruynWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.ORCID 0000-0002-5088-2158
Catherine RiouWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.ORCID 0000-0001-9679-0745
Keith D KauffmanT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-7208-1565
Tuberculosis Imaging Program
Ian N MooreInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0391-6466
Franca Del NonnoPathology Unit, National Institute for Infectious Diseases "L. Spallanzani," Istituto Di Ricovero e Cura a Carattere Scientifico, Rome, Italy.ORCID 0000-0001-6664-9257
Linda PetroneTranslational Research Unit, Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases, Istituto Di Ricovero e Cura a Carattere Scientifico, Rome, Italy.ORCID 0000-0002-2593-3478
Delia GolettiTranslational Research Unit, Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases, Istituto Di Ricovero e Cura a Carattere Scientifico, Rome, Italy.ORCID 0000-0001-8360-4376
Adrian R MartineauInstitute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0001-5387-1721
David M LoweInstitute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0001-6102-2375
Mark R CronanIn Vivo Cell Biology of Infection Unit, Max Planck Institute for Infection Biology, Berlin, Germany.ORCID 0000-0002-3760-1649
Robert J WilkinsonWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.ORCID 0000-0002-2753-1800
Clifton E BarryWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.ORCID 0000-0002-2927-270X
Laura E ViaTuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6074-9521
Daniel L BarberT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-7008-7509
Amy D KlionHuman Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-4986-5326
Bruno B AndradeThe KAB group, Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador Brazil.ORCID 0000-0001-6833-3811
Yanzheng SongTuberculosis Center, Shanghai Emerging and Re-emerging Infectious Disease Institute, Fudan University, Shanghai, China.ORCID 0000-0003-0553-9307
Ka-Wing WongDepartment of Scientific Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0001-8356-5880
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0311-3233
National Institutes of Health · USFudan University · CNIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Cape Town · ZADuke University · USFundação Oswaldo Cruz · BRUniversity College London · GB
Funding
Tuberculosis Imaging ProgramZICAI001239 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2018 to 2025
$22.7MEosinophils and Eosinophil Activation in the Pathogenesis of Human DiseaseZIAAI001130 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KLION, AMY · 2010 to 2025
$22.5MImmune Regulation in Mycobacterial InfectionsZIAAI001171 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARBER, DANIEL · 2012 to 2025
$16.7MInnate inflammatory responses during pulmonary infectionsZIAAI001207 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MAYER-BARBER, KATRIN · 2015 to 2025
$13.6MInflammatory determinants of disease severity and treatment outcome in TB patientsU01AI115940 · NIAID · UNIVERSITY OF CAPE TOWN · PI SHER, ALAN, WILKINSON, ROBERT JOHN · 2015 to 2019
$1.1MCancer Research UKIntramural NIH HHSNIAID NIH HHS U01 AI115940NIH HHS U01AI115940Wellcome Trust 104803Wellcome Trust 203135Wellcome Trust FC0010218
Abstract
Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
Indexed as
AdultAnimalsEosinophilsFemaleGranulocytesHost-Pathogen InteractionsHumansLatent TuberculosisLungMacaca mulattaMaleMiceMice, Mutant StrainsMycobacterium tuberculosisTuberculosisZebrafish
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