Evidence map›Paper›PMID 34346867›Full record

ArticleeLife2021

How lung cancer cells change identity.

Mitchell S von Itzstein, Benjamin J Drapkin, John D Minna

Abstract readComment
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2023
    Article
  5. Cell Therapy with Human Reprogrammed CD8International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Mitchell S von ItzsteinDepartment of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0003-0530-3169
Benjamin J DrapkinDepartment of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-4824-7243
John D MinnaDepartment of Internal Medicine, Division of Hematology and Oncology, the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-7776-0767

Funding

Dissecting and overcoming cross-resistance to DNA damaging agents in SCLCK08CA237832 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DRAPKIN, BENJAMIN J · 2020 to 2024
$1.2M
NCI NIH HHS K08 CA237832
6 · The paper itself

Abstract

Changes in MAPK signaling allow lung cancer cells to transition between lineages that respond differently to treatment.

Indexed as

Lung NeoplasmsMAP Kinase Signaling SystemHumansLungcancer biologyERK signalinghumanlineage switchinglineage transformationlung cancer

Identifiers

PMID34346867
PMCPMC8337071

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.