Evidence map›Paper›PMID 34346856›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Precision-Enhancing Risk Stratification Tools for Selecting Optimal Treatment Durations in Tuberculosis Clinical Trials.

Marjorie Z Imperial, Patrick P J Phillips, Payam Nahid, Radojka M Savic

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07018076 (Candidate Clinical Correlate of Prognostic Outcome for TB Study), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07018076 recruitingnot on this mapstarted 2025, after this paper: background citation

Candidate Clinical Correlate of Prognostic Outcome for TB Study

TypeobservationalSponsorUniversity of California, San FranciscoRan2025 to 2027Enrolled750ConditionsTuberculosisArmsRS ratio, Blood-based host immune response assays
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Reported Tuberculosis Symptoms: An Inadequate Classifier of Disease State.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. REVOLUTIONIZING TUBERCULOSIS REGIMEN DEVELOPMENT.Transactions of the American Clinical and Climatological Association · 2025
    Review
  19. Article
  20. PET/CT guided tuberculosis treatment shortening: a randomized trial.medRxiv : the preprint server for health sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marjorie Z ImperialDepartment of Bioengineering and Therapeutic Sciences.ORCID 0000-0001-7434-3012
Patrick P J PhillipsUniversity of California, San Francisco, Center for Tuberculosis, and.ORCID 0000-0002-6336-7024
Payam NahidUniversity of California, San Francisco, Center for Tuberculosis, and.ORCID 0000-0003-2811-1311
Radojka M SavicDepartment of Bioengineering and Therapeutic Sciences.ORCID 0000-0003-3143-5579
San Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
PHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1M
Identifying Optimal Treatment Strategies for Tuberculosis TreatmentR01AI135124 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLAND, DAVID, SAVIC, RADOJKA · 2019 to 2023
$3.8M
NIAID NIH HHS R01 AI135124NIAID NIH HHS UM1 AI068634NIGMS NIH HHS T32 GM007175
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Administration ScheduleDuration of TherapyAdultAntitubercular AgentsClinical Trials as TopicFemaleHumansMalePractice Guidelines as TopicPrecision MedicineRifampinRisk AssessmentTuberculosis, PulmonaryYoung AdultAntitubercular AgentsRifampinclinical trial designoptimal treatment durationrisk stratificationstratified medicinetuberculosis therapeutics

Identifiers

PMID34346856
PMCPMC8663006
OpenAlexW3191249477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.