Evidence map›Paper›PMID 34346778›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury.

Joshuah M Gagan, Khoa Cao, Yu-An Zhang, Jianning Zhang, Taylor L Davidson, Johanne V Pastor, Orson W Moe, Connie C W Hsia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Investigating human lung resilience, its evolutionary history and its relation to COPD.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joshuah M GaganDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Khoa CaoDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Yu-An ZhangDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Jianning ZhangDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Taylor L DavidsonCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
Johanne V PastorDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Orson W MoeDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Connie C W HsiaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0003-1995-1407
The University of Texas Southwestern Medical Center · US

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney InjuryR01DK092461 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG · 2011 to 2021
$3.7M
Nanoparticle Drug Delivery in Post-Pneumonectomy Compensatory Lung GrowthU01HL111146 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIA, CONNIE C. W., NGUYEN, KYTAI TRUONG · 2012 to 2016
$3.2M
Klotho and Phosphate in Chronic Kidney Disease: Pathogenesis and TherapeuticsR01DK091392 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG, MOE, ORSON W · 2011 to 2021
$3.2M
Structural Plasticity in Compensatory Lung Growth and RemodelingR01HL134373 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIA, CONNIE C. W. · 2017 to 2020
$2.8M
Laser Scanning Confocal for UT Southwestern Live Cell Imaging FacilityS10OD021684 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2016 to 2016
$455k
NHLBI NIH HHS R01 HL134373NHLBI NIH HHS U01 HL111146NIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK091392NIDDK NIH HHS R01 DK092461NIH HHS S10 OD021684
6 · The paper itself

Abstract

Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of modest Klotho overexpression on acute lung injury (ALI) and recovery. Transgenic Klotho-overexpressing (

Indexed as

Acute Lung InjuryAnimalsCell LineCytoprotectionDNA Breaks, Double-StrandedDNA DamageFemaleGlucuronidaseHEK293 CellsHumansHyperoxiaKlotho ProteinsL-Lactate DehydrogenaseLungMaleMiceGlucuronidaseKlotho ProteinsL-Lactate DehydrogenaseSmokeDNA double strand breakshyperoxiakidneyoxidative stresssoluble Klotho

Identifiers

PMID34346778
PMCPMC8560398
OpenAlexW3188114309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.