Evidence map›Paper›PMID 34346771›Full record

ArticleJournal of virology2021

Murine Norovirus Infection Results in Anti-inflammatory Response Downstream of Amino Acid Depletion in Macrophages.

Michèle Brocard, Jia Lu, Belinda Hall, Khushboo Borah, Carla Moller-Levet, Iliana Georgana, Frederic Sorgeloos, Dany J V Beste, Ian G Goodfellow, Nicolas Locker

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michèle BrocardFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.
Jia LuDivision of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Belinda HallFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.
Khushboo BorahFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.
Carla Moller-LevetFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.
Iliana GeorganaDivision of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Frederic SorgeloosDivision of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Dany J V BesteFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.
Ian G GoodfellowDivision of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Nicolas LockerFaculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surreygrid.5475.3, Guildford, United Kingdom.ORCID 0000-0002-0053-2897
University of Surrey · GBUniversity of Cambridge · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Murine norovirus (MNV) infection results in a late translation shutoff that is proposed to contribute to the attenuated and delayed innate immune response observed both

Indexed as

Activating Transcription Factor 2AnimalsAntiviral AgentsCaliciviridae InfectionsCell LineEukaryotic Initiation Factor-2Immunity, InnateInflammationInterferonsMacrophagesMiceNorovirusProtein Serine-Threonine KinasesRAW 264.7 CellsRNA, Double-StrandedSignal TransductionActivating Transcription Factor 2Antiviral AgentsAtf2 protein, mouseEif2ak4 protein, mouseEukaryotic Initiation Factor-2InterferonsProtein Serine-Threonine KinasesRNA, Double-StrandedViral Nonstructural Proteinsnorovirusstress responsetranslation

Identifiers

PMID34346771
PMCPMC8475529
OpenAlexW3192903551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.