Evidence map›Paper›PMID 34346709›Full record

ArticlemSphere2021

Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak.

Laura Pérez-Lago, Helena Martínez-Lozano, Jose Antonio Pajares-Díaz, Arantxa Díaz-Gómez, Marina Machado, Pedro J Sola-Campoy, Marta Herranz, Maricela Valerio, María Olmedo, Julia Suárez-González and 12 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Transmission visualizations of healthcare infection clusters: A scoping review.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Laura Pérez-Lago *Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Helena Martínez-Lozano *Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Jose Antonio Pajares-Díaz *Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Arantxa Díaz-Gómez *Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Marina MachadoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Pedro J Sola-CampoyServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Marta HerranzServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Maricela ValerioServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
María OlmedoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Julia Suárez-GonzálezInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Víctor Quesada-CuboInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Maria Del Mar Gómez-RuizInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Nieves López-FresneñaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Ignacio Sánchez-ArcillaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Iñaki ComasInstituto de Biomedicina de Valencia-CSIC, Valencia, Spain.
Fernando González-CandelasJoint Research Unit, Infection and Public Health, FISABIO-University of Valencia, Institute for Integrative Systems Biology (I2SysBio), Valencia, Spain.
Sonia García de San JoséGerencia, Gregorio Marañón General University Hospital, Madrid, Spain.
Rafael BañaresInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Pilar CatalánServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Patricia MuñozServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Darío García de ViedmaServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Gregorio Marañón Microbiology-ID COVID-19 Study Group
Hospital General Universitario Gregorio Marañón · ESUniversidad Complutense de Madrid · ESInstituto de Biomedicina de Valencia · ESUniversitat de València · ES

Funding

MEC | Consejo Superior de Investigaciones Científicas (CSIC) PTI Salud GlobalMEC | Instituto de Salud Carlos III (ISCIII) COV20/00140: SeqCOVIDMEC | Instituto de Salud Carlos III (ISCIII) CP15/00075
6 · The paper itself

Abstract

SARS-CoV-2 nosocomial outbreaks in the first COVID-19 wave were likely associated with a shortage of personal protective equipment and scarce indications on control measures. Having covered these limitations, updates on current SARS-CoV-2 nosocomial outbreaks are required. We carried out an in-depth analysis of a 27-day nosocomial outbreak in a gastroenterology ward in our hospital, potentially involving 15 patients and 3 health care workers. Patients had stayed in one of three neighboring rooms in the ward. The severity of the infections in six of the cases and a high fatality rate made the clinicians suspect the possible involvement of a single virulent strain persisting in those rooms. Whole-genome sequencing (WGS) of the strains from 12 patients and 1 health care worker revealed an unexpected complexity. Five different SARS-CoV-2 strains were identified, two infecting a single patient each, ruling out their relationship with the outbreak; the remaining three strains were involved in three independent, overlapping, limited transmission clusters with three, three, and five cases. Whole-genome sequencing was key to understand the complexity of this outbreak.

Indexed as

AdolescentAdultAgedCOVID-19Cross InfectionDisease OutbreaksFemaleGenome, ViralHealth PersonnelHospitalsHumansMaleMiddle AgedPhylogenySARS-CoV-2Whole Genome SequencingCOVID-19genomic epidemiologynosocomial transmissionSARS-CoV-2

Identifiers

PMID34346709
PMCPMC8386460
OpenAlexW3135203677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.