Evidence map›Paper›PMID 34346704›Full record

ArticlemSphere2021

Skin Metagenomic Sequence Analysis of Early Candida auris Outbreaks in U.S. Nursing Homes.

Xin Huang, Rory M Welsh, Clay Deming, Diana M Proctor, Pamela J Thomas, NISC Comparative Sequencing Program, Gabrielle M Gussin, Susan S Huang, Heidi H Kong, Meghan L Bentz and 7 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 39 citations in OpenAlex.

  1. Active Screening forJournal of fungi (Basel, Switzerland) · 2026
    Review
  2. ManagingInfection prevention in practice · 2026
    Article
  3. Article
  4. Journal of fungi (Basel, Switzerland) · 2026
    Review
  5. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  6. Article
  7. Article
  8. Microorganisms · 2025
    Article
  9. Article
  10. Article
  11. Annual review of medicine · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Rapid Environmental Contamination With Candida auris and Multidrug-Resistant Bacterial Pathogens Near Colonized Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  16. Article
  17. Review
  18. Infection and immunity · 2023
    Article
  19. Review
  20. Clorgyline Analogs Synergize with Azoles against Drug Efflux inJournal of fungi (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Xin Huang *Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Rory M Welsh *Mycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Clay DemingMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Diana M ProctorMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Pamela J ThomasNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland, USA.
NISC Comparative Sequencing ProgramNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland, USA.
Gabrielle M GussinDivision of Infectious Diseases, Department of Medicine, University of California Irvine School of Medicine, Irvine, California, USA.
Susan S HuangDivision of Infectious Diseases, Department of Medicine, University of California Irvine School of Medicine, Irvine, California, USA.
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Meghan L BentzMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Snigdha VallabhaneniMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Tom ChillerMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Brendan R JacksonMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Kaitlin ForsbergMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Sean ConlanMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Anastasia P LitvintsevaMycotic Diseases Branch, Centers for Disease Control and Preventiongrid.416738.f (CDC), Atlanta, Georgia, USA.
Julia A SegreMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Centers for Disease Control and Prevention · USNational Institutes of Health · USUniversity of California, Irvine · US

Funding

Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6M
Microbial genomics of hospital-associated pathogensZIAHG200382 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2012 to 2025
$9.1M
6 · The paper itself

Abstract

Candida auris is a human fungal pathogen classified as an urgent threat to the delivery of health care due to its extensive antimicrobial resistance and the high mortality rates associated with invasive infections. Global outbreaks have occurred in health care facilities, particularly, long-term care hospitals and nursing homes. Skin is the primary site of colonization for C. auris. To accelerate research studies, we developed microbiome sequencing protocols, including amplicon and metagenomic sequencing, directly from patient samples at health care facilities with ongoing C. auris outbreaks. We characterized the skin mycobiome with a database optimized to classify

Indexed as

Candida aurisCandidiasisDisease OutbreaksHumansMetagenomeMetagenomicsMycobiomeNursing HomesRisk FactorsSkinUnited StatesCandida aurisfungal pathogenITS1medical mycologymycobiome

Identifiers

PMID34346704
PMCPMC8386442
OpenAlexW3192570511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.