Evidence map›Paper›PMID 34346702›Full record

ArticlemSphere2021

Identification of a Family of

N Plaza, I M Urrutia, K Garcia, M K Waldor, C J Blondel

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Microbial genomics · 2023
    Article
  6. Article
  7. Review
  8. Virulence · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

N PlazaInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chilegrid.441837.d, Santiago, Chile.
I M UrrutiaInstituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
K GarciaInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chilegrid.441837.d, Santiago, Chile.
M K WaldorDivision of Infectious Diseases, Brigham & Women's Hospital, Boston, Massachusetts, USA.
C J BlondelInstituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Universidad Andrés Bello · CLBrigham and Women's Hospital · USUniversidad Autónoma de Chile · CL

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Howard Hughes Medical Institute (HHMI) 55008749NIAID NIH HHS R01 AI042347
6 · The paper itself

Abstract

Vibrio parahaemolyticus is a marine Gram-negative bacterium that is a leading cause of seafood-borne gastroenteritis. Pandemic strains of V. parahaemolyticus rely on a specialized protein secretion machinery known as the type III secretion system 2 (T3SS2) to cause disease. The T3SS2 mediates the delivery of effector proteins into the cytosol of infected cells, where they subvert multiple cellular pathways. Here, we identify a new T3SS2 effector protein encoded by VPA1328 (VP_RS21530) in V. parahaemolyticus RIMD2210633. Bioinformatic analysis revealed that VPA1328 is part of a larger family of uncharacterized T3SS effector proteins with homology to the VopG effector protein in Vibrio cholerae AM-19226. These VopG-like proteins are found in many but not all T3SS2 gene clusters and are distributed among diverse

Indexed as

Bacterial ProteinsCaco-2 CellsComputational BiologyGene Expression Regulation, BacterialHumansInterleukin-8Multigene FamilyProtein Serine-Threonine KinasesProtein TransportSerineType III Secretion SystemsVibrio parahaemolyticusBacterial ProteinsInterleukin-8Protein Serine-Threonine KinasesSerineType III Secretion Systemsfoodborne pathogenNleHT3SST3SS2type III secretion systemVibrio parahaemolyticusVopGVPA1328

Identifiers

PMID34346702
PMCPMC8386410
OpenAlexW3190423271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.