Evidence map›Paper›PMID 34346700›Full record

ArticlemSphere2021

Evolutionary and Functional Analysis of Coagulase Positivity among the Staphylococci.

Amy C Pickering, Gonzalo Yebra, Xiangyu Gong, Mariya I Goncheva, Bryan A Wee, Alison C MacFadyen, Lukas F Muehlbauer, Joana Alves, Robyn A Cartwright, Gavin K Paterson and 1 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  11. Unveiling the Relevance of the Oral Cavity as aPathogens (Basel, Switzerland) · 2023
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  12. Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022
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  13. Microorganisms · 2022
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  14. Comparative genomics study ofFrontiers in microbiology · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Amy C PickeringThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Gonzalo YebraThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Xiangyu GongThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Mariya I GonchevaThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Bryan A WeeThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Alison C MacFadyenThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Lukas F MuehlbauerThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Joana AlvesThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Robyn A CartwrightThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Gavin K PatersonThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
J Ross FitzgeraldThe Roslin Institute and Edinburgh Infectious Diseases, University of Edinburghgrid.4305.2, Easter Bush, Midlothian, Scotland, United Kingdom.
Roslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20002173Biotechnology and Biological Sciences Research Council BBS/E/D/20002174Medical Research Council MR/N02995X/1Wellcome Trust
6 · The paper itself

Abstract

The bacterial genus Staphylococcus comprises a large group of pathogenic and nonpathogenic species associated with an array of host species. Staphylococci are differentiated into coagulase-positive or coagulase-negative groups based on the capacity to promote clotting of plasma, a phenotype historically associated with the ability to cause disease. However, the genetic basis of this important diagnostic and pathogenic trait across the genus has not been examined to date. Here, we selected 54 representative staphylococcal species and subspecies to examine coagulation of plasma derived from six representative host species. In total, 13 staphylococcal species mediated coagulation of plasma from at least one host species including one previously identified as coagulase negative (Staphylococcus condimenti). Comparative genomic analysis revealed that coagulase activity correlated with the presence of a gene (

Indexed as

Evolution, MolecularAnimalsBacterial ProteinsBirdsBlood CoagulationCoagulaseGenome, BacterialGenomicsHorsesHumansPhylogenyRabbitsStaphylococcal InfectionsStaphylococcusSwineVirulence FactorsBacterial ProteinsCoagulaseVirulence Factorscoagulasecoagulase-positive staphylococcicoagulationdiagnosticsevolutionhost specificityphylogenyStaphylococcusvon Willebrand binding protein

Identifiers

PMID34346700
PMCPMC8386474
OpenAlexW3191848969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.