ArticleHuman brain mapping2021
Early motor network connectivity after stroke: An interplay of general reorganization and state-specific compensation.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Efficacy of combined non-invasive brain stimulation and robot-assisted gait training on lower extremity recovery post-stroke: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2025Pooled it
- The effects of rTMS on motor recovery after stroke: a systematic review of fMRI studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Neuroplastic Mechanisms of Acupuncture in Post-Stroke Motor Recovery: A Randomized Multimodal MRI Trial.CNS neuroscience & therapeutics · 2026Trial
- Contralaterally controlled neuromuscular electrical stimulation-induced changes in functional connectivity in patients with stroke assessed using functional near-infrared spectroscopy.Frontiers in neural circuits · 2022Trial
- Structural reserve-dependent cortical rerouting of motor control after stroke.Brain : a journal of neurology · 2026Article
- Adaptive Neural Reorganization Enables Real-Time Finger-Level Robotic Control in BCI-Naïve Stroke Survivors.bioRxiv : the preprint server for biology · 2026Article
- Associations Between Early Functional Brain Network Topology and 6-Month Upper Limb Motor Outcomes in Stroke Patients.Translational stroke research · 2026Article
- The onco-functional reorganization of language network underlying metaplasticity induced by gliomas.Frontiers in oncology · 2026Article
- Estimation of Stroke's Motor Function Ability Using Multimodal Biomarkers and the Role of Contralesional Motor Area.Brain and behavior · 2025Article
- Corticospinal premotor fibers facilitate complex motor control after stroke.Annals of clinical and translational neurology · 2024Article
- Identifying biomarkers related to motor function in chronic stroke: A fNIRS and TMS study.CNS neuroscience & therapeutics · 2024Article
- Disrupted Effective Connectivity within the Fronto-Thalamic Circuit in Pontine Infarction: A Spectral Dynamic Causal Modeling Study.Brain sciences · 2024Article
- Variation in brain connectivity during motor imagery and motor execution in stroke patients based on electroencephalography.Frontiers in neuroscience · 2024Article
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Early functional connectivity alterations in contralesional motor networks influence outcome after severe stroke: a preliminary analysis.Scientific reports · 2023Article
- Predicting poststroke dyskinesia with resting-state functional connectivity in the motor network.Neurophotonics · 2023Article
- Recombination of the right cerebral cortex in patients with left side USN after stroke: fNIRS evidence from resting state.Frontiers in neurology · 2023Article
- The role of corticospinal and extrapyramidal pathways in motor impairment after stroke.Brain communications · 2023Article
- Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability-A Resting-State fMRI Study.Frontiers in neuroscience · 2022Article
- Aberrant interhemispheric functional reciprocities of the default mode network and motor network in subcortical ischemic stroke patients with motor impairment: A longitudinal study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor recovery after stroke relies on functional reorganization of the motor network, which is commonly assessed via functional magnetic resonance imaging (fMRI)-based resting-state functional connectivity (rsFC) or task-related effective connectivity (trEC). Measures of either connectivity mode have been shown to successfully explain motor impairment post-stroke, posing the question whether motor impairment is more closely reflected by rsFC or trEC. Moreover, highly similar changes in ipsilesional and interhemispheric motor network connectivity have been reported for both rsFC and trEC after stroke, suggesting that altered rsFC and trEC may capture similar aspects of information integration in the motor network reflecting principle, state-independent mechanisms of network reorganization rather than state-specific compensation strategies. To address this question, we conducted the first direct comparison of rsFC and trEC in a sample of early subacute stroke patients (n = 26, included on average 7.3 days post-stroke). We found that both rsFC and trEC explained motor impairment across patients, stressing the clinical potential of fMRI-based connectivity. Importantly, intrahemispheric connectivity between ipsilesional M1 and premotor areas depended on the activation state, whereas interhemispheric connectivity between homologs was state-independent. From a mechanistic perspective, our results may thus arise from two distinct aspects of motor network plasticity: task-specific compensation within the ipsilesional hemisphere and a more fundamental form of reorganization between hemispheres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.