ArticleGut microbes
Distinct gut microbial compositional and functional changes associated with impaired inhibitory control in patients with cirrhosis.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Neurotransmitter-mediated gut-brain axis: a bibliometric analysis of research trends and knowledge structure.Frontiers in microbiology · 2026Pooled it
- The redefined identity ofJournal of bacteriology · 2026Review
- The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis.Life (Basel, Switzerland) · 2025Review
- Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes.Science advances · 2025Review
- The analysis of the gut microbiome during liver disease progression led to the identification of biomarkers for related mild cognitive impairment.Frontiers in microbiology · 2025Article
- Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension.World journal of gastroenterology · 2024Observational
- The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis.BMC medical genomics · 2024Article
- Gut microbiome in alcohol use disorder: Implications for health outcomes and therapeutic strategies-a literature review.World journal of methodology · 2024Review
- Review
- Alterations in gut virome are associated with cognitive function and minimal hepatic encephalopathy cross-sectionally and longitudinally in cirrhosis.Gut microbes · 2023Article
- An Immunological Perspective on the Mechanism of Drug Induced Liver Injury: Focused on Drugs for Treatment of Hepatocellular Carcinoma and Liver Transplantation.International journal of molecular sciences · 2023Review
- The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers.EBioMedicine · 2023Article
- Role of gut microbiota in the pathogenesis and therapeutics of minimal hepatic encephalopathyWorld journal of gastroenterology · 2023Review
- Review
- Intestinal Microbiota Participates in the Protective Effect of HO-1/BMMSCs on Liver Transplantation With Steatotic Liver Grafts in Rats.Frontiers in microbiology · 2022Article
- Dynamic Alterations of the Gut Microbial Pyrimidine and Purine Metabolism in the Development of Liver Cirrhosis.Frontiers in molecular biosciences · 2021Article
- Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis.Gut microbesArticle
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Most cirrhosis etiologies, such as alcohol, hepatitis C, and obesity, involve behavior that require the loss of inhibitory control. Once cirrhosis develops, patients can also develop cognitive impairment due to minimal hepatic encephalopathy (MHE). Both processes could have distinct imprints on the gut-liver-brain axis. Determine the impact of inhibitory control versus traditional cirrhosis-related cognitive performance on gut microbial composition and function. Outpatients with cirrhosis underwent two tests for MHE: inhibitory control test (MHEICT, computerized associated with response inhibition) and psychometric hepatic encephalopathy score (MHEPHES, paper-pencil HE-specific associated with subcortical impairment) along with stool collection for metagenomics. MHEICT/not, MHEPHES/not, and discordant (positive on one test but negative on the other) were analyzed for demographics, bacterial species, and gut-brain modules (GBM) using multi-variable analyses. Ninety-seven patients [47 (49%) MHEPHES, 76 (78%) MHEICT, 41 discordant] were enrolled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.