Evidence map›Paper›PMID 34346225›Full record

ArticleEnvironmental science & technology2021

Lack of Detectable Direct Effects of Silver and Silver Nanoparticles on Mitochondria in Mouse Hepatocytes.

Lu Wang, Danielle F Mello, Robert M Zucker, Nelson A Rivera, Nicholas M K Rogers, Nicholas K Geitner, William K Boyes, Mark R Wiesner, Heileen Hsu-Kim, Joel N Meyer

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Environmental science & technology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lu WangNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-4614-4427
Danielle F MelloNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Robert M ZuckerReproductive and Developmental Toxicology Branch, Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27709, United States.
Nelson A RiveraDepartment of Civil & Environmental Engineering, Duke University, Durham, North Carolina 27708, United States.
Nicholas M K RogersDepartment of Civil & Environmental Engineering, Duke University, Durham, North Carolina 27708, United States.
Nicholas K GeitnerReproductive and Developmental Toxicology Branch, Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27709, United States.
William K BoyesReproductive and Developmental Toxicology Branch, Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27709, United States.ORCID 0000-0002-3598-0032
Mark R WiesnerDepartment of Civil & Environmental Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0002-0823-5045
Heileen Hsu-KimDepartment of Civil & Environmental Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0003-0675-4308
Joel N MeyerNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Duke University · USEnvironmental Protection Agency · USChongqing University · CN

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Are mitochondria a major target of antimicrobial silver nanoparticles?R21ES026743 · NIEHS · DUKE UNIVERSITY · PI MEYER, JOEL NEWMAN · 2017 to 2018
$437k
NIEHS NIH HHS P42 ES010356NIEHS NIH HHS R21 ES026743NIEHS NIH HHS T32 ES021432
6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are well-proven antimicrobial nanomaterials, yet little is elucidated regarding the mechanism underlying cytotoxicity induced by these nanoparticles. Here, we tested the hypothesis that mitochondria are primary intracellular targets of two AgNPs and silver ions in mouse hepatocytes (AML12) cultured in glucose- and galactose-based media. AML12 cells were more sensitive to mitochondrial uncoupling when grown with galactose rather than glucose. However, 24 h treatments with 15 nm AgNPs and 6 nm GA-AgNPs (5 and 10 μg/mL) and AgNO

Indexed as

extracellular flux analysisgalactoseglucosemitochondrial metabolismnanotoxicitysilver nanoparticles

Identifiers

PMID34346225
PMCPMC8814061
OpenAlexW3189292930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.