ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2021
Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Genetics of skeletal proportions across two different populations.American journal of human genetics · 2026Article
- Genetic regulation of body size and morphology from adolescence to early adulthood.Pediatric research · 2026Article
- Metabolic factors influencing the efficacy of recombinant human growth hormone therapy in children with short stature.Frontiers in endocrinology · 2025Article
- Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci.Cell genomics · 2023Article
- Functional screens refine height GWAS loci.Cell genomics · 2023Article
- Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate.Bone research · 2023Article
- Genetic regulation of body size and morphology in children: a twin study of 22 anthropometric traits.International journal of obesity (2005) · 2023Article
- The genetic architecture of the human skeletal form.bioRxiv : the preprint server for biology · 2023Article
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5 authors at 3 institutions in 1 country.
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Abstract
Human adult height reflects the outcome of childhood skeletal growth. Growth plate (epiphyseal) chondrocytes are key determinants of height. As epiphyseal chondrocytes mature and proliferate, they pass through three developmental stages, which are organized into three distinct layers in the growth plate: (i) resting (round), (ii) proliferative (flat), and (iii) hypertrophic. Recent genomewide association studies (GWASs) of human height identified numerous associated loci, which are enriched for genes expressed in growth plate chondrocytes. However, it remains unclear which specific genes expressed in which layers of the growth plate regulate skeletal growth and human height. To connect the genetics of height and growth plate biology, we analyzed GWAS data through the lens of gene expression in the three dissected layers of murine newborn tibial growth plate. For each gene, we derived a specificity score for each growth plate layer and regressed these scores against gene-level p values from recent height GWAS data. We found that specificity for expression in the round cell layer, which contains chondrocytes early in maturation, is significantly associated with height GWAS p values (p = 8.5 × 10
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