ArticleJournal of the American Geriatrics Society2021
Functional decline among older cancer survivors in the Baltimore longitudinal study of aging.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Sarcopenia interventions targeted at improving muscle health in adults with cancer: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Self-reported health, function, and use of health care services in older prostate cancer survivors compared to matched controls: a cross-sectional study.Journal of cancer survivorship : research and practice · 2026Article
- Exploring the Impact of Gender and Income on Concerns Reported by Cancer Survivors Aged ≥85 Years in Canada: A Secondary Analysis of the Canadian Transitions Survey.Current oncology (Toronto, Ont.) · 2026Article
- Review
- Article
- Life-space mobility trajectory patterns and associated characteristics in older cancer survivors: a secondary data analysis.BMC geriatrics · 2025Article
- Application of Patient-Generated Health Data Among Older Adults With Cancer: Scoping Review.Journal of medical Internet research · 2025Article
- An association of cognitive function with mobile metrics of community walking in older cancer survivors: A pilot study.Journal of geriatric oncology · 2025Article
- Pain and Frailty in Childhood Cancer Survivors: A Narrative Review.Current oncology (Toronto, Ont.) · 2024Review
- Article
- A scoping review of diet and exercise interventions for older cancer survivors' physical function.Journal of geriatric oncology · 2024Article
- Utilization of a primary care-based cancer survivorship clinic: patterns and patient characteristics.Journal of cancer survivorship : research and practice · 2024Article
- Factors Associated with Discharge Destination in Patients with Bone Metastases.Medicina (Kaunas, Lithuania) · 2024Article
- Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18-39 Years) Cancer Survivors.The oncologist · 2024Article
- Associations between performance-based and patient-reported physical functioning and real-world mobile sensor metrics in older cancer survivors: A pilot study.Journal of geriatric oncology · 2024Article
- E-PROOF: E-intervention for protein intake and resistance training to optimize function: A study protocol.PloS one · 2024Article
- Long-term late effects in older gastric cancer survivors: Survival analysis using Cox hazard regression model by retrospective electronic health records.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Prospective, Multi-Institutional Observational Study of Deterioration in Activities of Daily Living in Elderly Patients After Lung Cancer Surgery.JTO clinical and research reports · 2023Article
- Feasibility and Implementation of an Oncology Rehabilitation Triage Clinic: Assessing Rehabilitation, Exercise Need, and Triage Pathways within the Alberta Cancer Exercise-Neuro-Oncology Study.Current oncology (Toronto, Ont.) · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEvidence has begun to emerge indicating that cancer survivors experience accelerated aging. This study examines this phenomenon by evaluating trajectories of functional decline in older adults with a history of a cancer diagnosis relative to those without a history of cancer.
methodsCommunity dwelling healthy volunteers in the Baltimore Longitudinal Study of Aging were evaluated in the Clinical Research Unit of the National Institute on Aging Intramural Research Program. Between 2006 and 2019, 1728 men and women (aged 22-100) underwent clinical evaluation of functional status; 359 reported having a history of cancer. Longitudinal associations between self-reported cancer history and measures of functional decline were examined using generalized estimating equations. Additionally, time-to-event and Cox proportional hazards models were used to examine trajectories of decline. Where appropriate, age-stratified associations were examined, and models were adjusted for sex, body mass index, race, smoking status, education, and number of comorbid conditions.
resultsAmong all participants, a history of cancer was associated with 1.42 (95% CI 1.11-1.81) greater odds of weak grip strength. Among older participants (>65 years of age), those with a history of cancer had 1.61 (95% CI 1.28, 2.02) greater odds of slow gait speed and a 0.11 unit (95% CI 0.19-0.03) lower physical performance score than those with no cancer history. Time-to-event analysis showed that older individuals with a history of cancer experienced steeper decline in grip strength and gait speed than older adults with no history of cancer (p < 0.01).
conclusionCancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. Observational and intervention studies are needed for prevention, mitigation, and/or reversal of aging-related effects of cancer and its treatment.
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