ArticleActa obstetricia et gynecologica Scandinavica2021
High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring.
Article in Acta obstetricia et gynecologica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Statin use in pregnancy and risk of congenital malformations: a Norwegian nationwide study.European heart journal · 2026Pooled it
- Maternal Blood as a Window to the Fetal Heart: Novel Biomarkers for Early Detection of Septal Defects.Biomedicines · 2026Review
- Article
- Precision fetal cardiology detects cyanotic congenital heart disease using maternal saliva metabolome and artificial intelligence.Scientific reports · 2025Article
- Article
- Biochemical indicators, cell apoptosis, and metabolomic analyses of the low-temperature stress response and cold tolerance mechanisms in Litopenaeus vannamei.Scientific reports · 2024Article
- Maternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring.BMC pregnancy and childbirth · 2024Article
- Association between lipid profile in early pregnancy and the risk of congenital heart disease in offspring: a prospective cohort study.Scientific reports · 2024Article
- Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring.JAMA network open · 2024Article
- Article
- The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses.Journal of cardiovascular development and disease · 2022Article
- High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring.Acta obstetricia et gynecologica Scandinavica · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to investigate whether maternal blood lipid levels during early pregnancy are associated with the occurrence of congenital heart disease (CHD) in their offspring. MATERIAL AND
methodsIn this single-center case-control study, mothers of offspring with CHD (n = 230) and without CHD (n = 381) were included. Maternal lipid levels were determined on fasting blood samples taken in the first trimester. Relevant demographic and clinical data were extracted from the medical records. Maternal lipid profile was compared between the two groups, and regression analysis was performed to evaluate the association between lipid profile and CHD risk in offspring.
resultsCompared with the control group, levels of triglyceride, apolipoprotein-A1, and apolipoprotein-B in early pregnancy were significantly higher in the CHD group. Multivariate analyses showed that triglyceride (odds ratio [OR] 2.46, 95% CI 1.62-3.73, p < 0.01), total/high-density lipoprotein cholesterol (OR 2.10, 95% CI 1.07-4.13, p = 0.03), and apolipoprotein-A1 (OR 2.73, 95% CI 1.16-6.40, p = 0.02) were positively associated with CHD risk in offspring.
conclusionsElevated maternal lipid profile was associated with increased risk of CHD in offspring.
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