Evidence map›Paper›PMID 34345983›Full record

ArticleCell biochemistry and biophysics2022

INitial Steps of Insulin Action in Parotid Glands of Male Wistar Rats.

André Guaraci DeVito-Moraes, Victor Di Donato Marques, Luciana Chagas Caperuto, Flavia Kazue Ibuki, Fernando Neves Nogueira, Carlos Eduardo Francci, Carla Roberta de Oliveira Carvalho

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

André Guaraci DeVito-MoraesDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil. adevito@alumni.usp.br.ORCID http://orcid.org/0000-0001-8070-0207
Victor Di Donato MarquesDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Luciana Chagas CaperutoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Flavia Kazue IbukiDepartment of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo (USP), Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Fernando Neves NogueiraDepartment of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo (USP), Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Carlos Eduardo FrancciDepartment of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo (USP), Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Carla Roberta de Oliveira CarvalhoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Universidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 03/04153-4
6 · The paper itself

Abstract

The parotid gland is the largest salivary gland. It produces watery saliva, rich in proteins (amylase, lysozymes, and antibodies). Due to the gland's morphological cytoarchitecture composed of only serous acini, it contributes almost 50% of total salivary volume upon stimulation. It has been reported that the prevalence of saliva secretion impairments, periodontitis, delayed wound healing, and xerostomia increase in diabetic patients. Herein we evaluated the acute effects of insulin on insulin receptor phosphorylation status and its substrates IRS-1 and IRS-2 in the parotid glands of adult male Wistar rats, using Western blot analyses. We confirmed an acute effect of insulin on IR/IRS/PI3K/Akt and MAPK intracellular pathway activation in the parotid glands of male Wistar rats similar to the classical metabolic targets of the hormone, like the liver.

Indexed as

Parotid GlandXerostomiaAnimalsInsulinMaleRatsRats, WistarSignal TransductionInsulinInsulinIntracellular Signaling, Rats.Parotid Gland

Identifiers

PMID34345983
OpenAlexW3190762546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.