ArticleJournal of neurology2022
Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder.
Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Sex differences in alpha-synucleinopathies: a systematic review.Frontiers in neurology · 2023Pooled it
- Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder.Nature communications · 2025Article
- Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson's disease and mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.Frontiers in neurology · 2025Article
- A multi-site study on sex differences in cortical thickness in non-demented Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Sex differences in brain atrophy in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors.Frontiers in neurology · 2024Article
- Association of coffee consumption and striatal volume in patients with Parkinson's disease and healthy controls.CNS neuroscience & therapeutics · 2023Article
- Age and sex differentially shape brain networks in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population.Data in brief · 2023Article
- MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023Review
- Morphological changes in Parkinson's disease based on magnetic resonance imaging: A mini-review of subcortical structures segmentation and shape analysis.World journal of psychiatry · 2022Review
- The X factor in neurodegeneration.The Journal of experimental medicine · 2022Article
- Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study.Biology of sex differences · 2022Article
- Sex Differences in Parkinson's Disease: From Bench to Bedside.Brain sciences · 2022Article
- The structural changes of gray matter in Parkinson disease patients with mild cognitive impairments.PloS one · 2022Article
- Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in MaleFrontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson's disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD).
methodsMagnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data.
resultsMales showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group.
conclusionMale sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research.
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