Evidence map›Paper›PMID 34345863›Full record

ArticleCurrent research in toxicology2021

Estrogenic activity of capsule coffee using the VM7Luc4E2 assay.

Junichi R Sakaki, Melissa M Melough, Cathy Z Yang, Anthony A Provatas, Christopher Perkins, Ock K Chun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Junichi R SakakiDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
Melissa M MeloughDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
Cathy Z YangCertiChem Inc., Austin, TX, USA.
Anthony A ProvatasCenter for Environmental Sciences and Engineering, University of Connecticut, Storrs, CT, USA.
Christopher PerkinsCenter for Environmental Sciences and Engineering, University of Connecticut, Storrs, CT, USA.
Ock K ChunDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
University of Connecticut · USCertiChem (United States) · US

Funding

Assessment of Risk of Exposure to Estrogenic Chemicals via Capsule Coffee ConsumptionR03ES027983 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI CHUN, OCK K. · 2018 to 2019
$160k
NIEHS NIH HHS R03 ES027983
6 · The paper itself

Abstract

Coffee brewed from capsule machines may contain estrogenic chemicals migrated from plastic, but the estrogenic activity of capsule coffee has not been evaluated. This study evaluated the estrogenic activity of capsule coffee using the VM7Luc4E2 estrogen receptor transcriptional activation assay. Estrogenic potentials of six capsule coffee samples were calculated using relative maximum amplitude response of E2 (>15%RME2 indicative of estrogenic activity) and estradiol equivalent factor (EEF). Estrogenic chemical content was determined using ultra-performance liquid chromatography with tandem mass spectrometry. All capsule coffee samples possessed estrogenic activity (48-56%RME2). EEFs were 6-7 orders of magnitude lower than that of E2, (1.2 × 10

Indexed as

4-NP, 4-nonylphenolbisphenol ABPA, bisphenol ABP, benzophenoneBPF, bisphenol FBPS, bisphenol SCapsuleCoffeeDBP, dibutyl phthalateE2, 17β-estradiolEEF, estradiol equivalent factorEEQ, estradiol equivalent concentrationEstrogenEstrogenic activityHPLC, high-performance liquid chromatographyPlasticRLU, relative luminescence unitsRME2, relative maximum amplitude response of E2UPLC-MS/MS, ultra-performance liquid chromatography with tandem mass spectrometry

Identifiers

PMID34345863
PMCPMC8320625
OpenAlexW3161813647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.