Evidence map›Paper›PMID 34345855›Full record

ArticleCurrent research in toxicology2021

Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.

Lukasz Czekala, Roman Wieczorek, Liam Simms, Fan Yu, Jessica Budde, Edgar Trelles Sticken, Kathryn Rudd, Thomas Verron, Oleg Brinster, Matthew Stevenson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Current research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Elevated COAllergy · 2026
    Article
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  4. Review
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  9. AnCurrent research in toxicology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Lukasz CzekalaImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Roman WieczorekReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Liam SimmsImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Fan YuImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Jessica BuddeReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Edgar Trelles StickenReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Kathryn RuddImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Thomas VerronImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Oleg BrinsterReemtsma Cigarettenfabriken GmbH, An Imperial Brands PLC Company, Albert-EinsteinRing-7, D-22761 Hamburg, Germany.
Matthew StevensonImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Tanvir WaleleImperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, United Kingdom.
Imperial Brands (United Kingdom) · GBBritish American Tobacco (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smoking is a cause of serious diseases in smokers including chronic respiratory diseases. This study aimed to evaluate the tobacco harm reduction (THR) potential of an electronic vapor product (EVP,

Indexed as

2D, Two Dimensional3D, Three Dimensional3R4F, Scientific Reference Tobacco Cigarette (University of Kentucky)ALI, Air-Liquid InterfaceANOVA, Analysis of VarianceAOP, Adverse Outcome PathwayCAA, Cilia Active AreaCBF, Cilia Beat FrequencyCigaretteCiliaCOPD, Chronic Obstructive Pulmonary DiseaseCYP450, Cytochrome P450DPBS, Dulbecco's phosphate-buffered saline containing Ca2+ and Mg2+EGFR, Epidermal Growth Factor ReceptorElectronic vapor productEVP, Electronic Vapor ProductFOX-J1, Forkhead Box J1 proteinH&E, Hematoxylin and EosinIIVS, Institute for In Vitro SciencesIL-13, Interleukin 13IL-1β, Interleukin 1 BetaIL-6, Interleukin-6IL-8, Interleukin-8ImmunohistochemistryISO, International Organization for StandardizationKERs, Key Event RelationshipsKEs, Key EventsLDH, Lactate DehydrogenaseMIE, Molecular Initiating EventMMP-1, Matrix Metalloproteinase-1MMP-3, Matrix Metalloproteinase-3MMP-9, Matrix Metalloproteinase-9MUC5AC, Mucin 5AC ProteinMWP, Multi-Well PlateNKT, Natural Killer T CellsOrganotypic tissue modelPBS, Phosphate Buffered SalinePMN, polymorphonuclearPro-inflammatory markersSAEIVS, Smoke Aerosol Exposure In Vitro SystemTEER, Transepithelial Electrical ResistanceTHR, Tobacco Harm ReductionTNF-α, Tumor Necrosis Factor AlphaTPM, Total Particulate Matter

Identifiers

PMID34345855
PMCPMC8320624
OpenAlexW3133337931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.