Evidence map›Paper›PMID 34345844›Full record

ArticleCurrent research in toxicology2020

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty.

Jorge W F Barros, Karolina S Tonon, Cibele S Borges, Patrícia V Silva, Ana F Q Lozano, Tainá L Pacheco, Janete A Anselmo-Franci, Wilma G Kempinas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jorge W F BarrosGraduate Program in Cell and Structural Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Karolina S TononDepartment of Structural and Functional Biology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, SP, Brazil.
Cibele S BorgesDepartment of Structural and Functional Biology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, SP, Brazil.
Patrícia V SilvaDepartment of Structural and Functional Biology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, SP, Brazil.
Ana F Q LozanoGraduate Program in Cell and Structural Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Tainá L PachecoGraduate Program in Cell and Structural Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Janete A Anselmo-FranciDepartment of Morphology, Stomatology and Physiology, Dental School of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Wilma G KempinasDepartment of Structural and Functional Biology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins are a class of drugs that act lowering lipid levels by inhibiting cholesterol biosynthesis. Additionally, statins can act by "pleiotropic effects", related to the inhibition of synthesis of the other mevalonate pathway products. Rosuvastatin is a third-generation statin and has shown better results in reducing cholesterol concentrations when compared to other statins. Recent studies suggest that rosuvastatin may act as an endocrine disruptor that potentially damages the hormonal axis and, consequently reproductive development and function of male rats. However, the effects of rosuvastatin exposure on rat female reproductive parameters remain unknown. In this study female rats were exposed to rosuvastatin at the doses of 0 (control), 3, or 10 mg/Kg.bw

Indexed as

Pleiotropic effectsRat female reproductionRosuvastatinStatin

Identifiers

PMID34345844
PMCPMC8320644
OpenAlexW3107942910

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.