Evidence map›Paper›PMID 34345842›Full record

ArticleCurrent research in toxicology2020

Lactational exposure to polychlorinated biphenyls is higher in overweight /obese women and associated with altered infant growth trajectory: A pilot study.

Lindsay Ellsworth, Harlan McCaffery, Sergei Chernyak, Stephanie Lam, Robert M Sargis, Vasantha Padmanabhan, Brigid Gregg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lindsay EllsworthDivision of Neonatal-Perinatal Medicine, Department of Pediatrics and Communicable Diseases, 1540 E. Medical Center Drive, University of Michigan, Ann Arbor, MI, United States.
Harlan McCafferyCenter for Human Growth and Development, University of Michigan, 300 N Ingalls St, Ann Arbor, MI, United States.
Sergei ChernyakEnvironmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, United States.
Stephanie LamDivision of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics and Communicable Diseases, University of Michigan, 1540 E. Medical Center Drive, University of Michigan, Ann Arbor, MI, United States.
Robert M SargisDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, 835 S. Wolcott, Chicago, IL, United States.
Vasantha PadmanabhanDepartment of Pediatrics and Communicable Diseases, University of Michigan, 1540 E. Medical Center Drive, University of Michigan, Ann Arbor, MI, United States.
Brigid GreggDivision of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics and Communicable Diseases, University of Michigan, 1540 E. Medical Center Drive, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USUniversity of Illinois Chicago · US

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Postdoc Stipend Supplement: Developmental Origins of Metabolic Disorders T32T32DK071212 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON, Kanakadurga Singer · 2005 to 2026
$5.4M
NIDDK NIH HHS T32 DK071212NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

backgroundInfant exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs), may contribute to developmental programming of long-term metabolic disease risk. PCBs persist given their lipophilicity and long half-lives, allowing them to bio-accumulate in adipose tissue. These compounds can then be excreted into maternal milk resulting in infant exposure.

objectiveTo determine the level of PCBs in milk from mothers with pre-pregnancy overweight and obese (OW/OB) versus normal weight status (NW) and evaluate the association of milk PCB levels with infant growth over the first 6 months of life.

methodsA pilot study of a subset of milk samples from mothers with NW (pre-pregnancy body mass index (BMI) < 25 kg/m

resultsTotal milk fat content did not differ by maternal weight status (

conclusionsMaternal overweight and obesity are associated with higher levels of total PCB congeners (132, 138, 153, 163, 180) in human milk. PCB congeners have negative associations with infant head circumference and weight trajectory over the first 6 months of life.

Indexed as

BMI, Body mass indexEDCs, Endocrine disrupting chemicalsGC/MS, Gas chromatography/mass spectrometryHCA, Head circumference-for-ageHMA, Human Milk AnalyzerHuman milkIMAGE, Infant Metabolism and Gestational EndocrinopathiesInfant growthLFA, Length-for-ageLOD, Limit of detectionPCBs, Polychlorinated biphenylsPolychlorinated biphenylsWFA, Weight-for-ageWFL, Weight-for-lengthWHO, World Health Organization

Identifiers

PMID34345842
PMCPMC8320629
OpenAlexW3097856695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.