Evidence map›Paper›PMID 34345841›Full record

ArticleCurrent research in toxicology2020

Acrylamide induces a thyroid allostasis-adaptive response in prepubertal exposed rats.

Viviane Matoso de Oliveira, Fernanda Ivanski, Isabela Medeiros de Oliveira, Paula Bargi-Souza, Dalton Luiz Schiessel, Marco Aurelio Romano, Renata Marino Romano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Viviane Matoso de OliveiraLaboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Fernanda IvanskiLaboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Isabela Medeiros de OliveiraLaboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Paula Bargi-SouzaDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos, 6627, 31270-901 Minas Gerais, Brazil.
Dalton Luiz SchiesselDepartment of Nutrition, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Marco Aurelio RomanoLaboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Renata Marino RomanoLaboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some endocrine-disrupting chemicals (EDCs) can affect the endocrine system through covalent interactions with specific sites, leading to deregulation of physiological homeostasis. The acrylamide (AA) present in some fried or baked foods is an example of an electrophile molecule that is able to form adducts with nucleophilic regions of nervous system proteins leading to neurological defects. A positive correlation between increased urinary AA metabolite concentration and reduced levels of thyroid hormones (TH) was described in adolescents and young adults. Thus, this study aimed to evaluate whether AA affects the physiology of the hypothalamus-pituitary-thyroid (HPT) axis and the possible repercussions in peripheral TH-target systems. For this, male Wistar rats were exposed to doses of 2.5 or 5.0 mg AA/Kg/day, based on the LOAEL (Lowest Observed Adverse Effect Level) during prepubertal development. The expression of molecular markers of HPT functionality was investigated in the hypothalamus, pituitary, thyroid, heart and liver, as well as the hormonal and lipid profiles in blood samples. Herein, we showed that AA acts as EDCs for thyroid gland function, increasing the transcript expression of several proteins related to TH synthesis and altering hypothalamus-pituitary-thyroid axis homeostasis, an effect evidenced by the higher levels of THs in the serum. Compensatory mechanisms were observed in TH-target tissues, such as an increase in

Indexed as

AA, acrylamideAcrylamideBW, body weightDIO1, iodothyronine deiodinase 1DIO2, iodothyronine deiodinase 2DIO3, iodothyronine deiodinase 3EDCs, endocrine-disrupting chemicalsEndocrine-disrupting chemicalsHDL, high-density lipoproteinsHPT, hypothalamus-pituitary-thyroid axisLDL, low lipoproteinsLOAEL, lowest Observed Adverse Effect LevelMCT-8, monocarboxylate transporter 8MYH6, myosin heavy chain 6NIS, sodium/iodide symporterNOAEL, no Observed Adverse Effect LevelPDS, pendrinPND, postnatal dayRfD, reference doseT3, triiodothyronineT4, thyroxineTDI, tolerable daily intakeTHRA1, thyroid hormone receptor alpha 1THRB2, thyroid hormone receptor beta 2TH, thyroid hormonesThyroidThyroid hormone metabolismTPO, thyroid peroxidaseTRHR, thyrotropin releasing hormone receptorTRH, thyrotropin releasing hormone hormoneTSH, thyroid hormone receptorTSH, thyrotropin

Identifiers

PMID34345841
PMCPMC8320623
OpenAlexW3096983087

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.