The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites.

Renato J Scialis, Carolina I Ghanem, José E Manautou

Open access · goldAbstract read

In one paragraph

Article in Current research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 57% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Renato J ScialisUniversity of Connecticut, School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA.

Carolina I GhanemUniversity of Connecticut, School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA.

José E ManautouUniversity of Connecticut, School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT 06269, USA.

University of Connecticut · USUniversity of Buenos Aires · AR

Funding

Transporter Expression in Response to HepatotoxicantsR01DK069557 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI MANAUTOU, JOSE E · 2005 to 2013

$2.4M

NIDDK NIH HHS R01 DK069557

6 · The paper itself

Abstract

During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response. We currently report that a single 400 mg/kg acetaminophen (APAP) dose to C57BL/6J mice led to an increase in multidrug resistance-associated (Mrp) 4 (

Indexed as

AcetaminophenALT, alanine aminotransferaseAMP, adenosine monophosphateAPAP, acetaminophenAPAP-CYS, acetaminophen cysteineAPAP-GLU, acetaminophen glucuronideAPAP-NAC, acetaminophen N-acetylcysteineAPAP-SUL, acetaminophen sulfateATP, adenosine triphosphateDCF-AG, diclofenac acyl glucuronideDCF, diclofenacDiclofenacFmo, flavin containing monooxygenaseInhibitionIS, internal standardLTC4, leukotriene C4MetaboliteMRP4MRP, multidrug resistance-associated proteinOH-DCF, 4′-hydroxy diclofenacPGE2, prostaglandin E2

Identifiers

PMID34345835

DOI10.1016/j.crtox.2020.04.002

PMCPMC8320619

OpenAlexW3023440205

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.