Evidence map›Paper›PMID 34345824›Full record

ArticleCritical care explorations2021

Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study.

Pedro Kurtz, Christian Storm, Marcio Soares, Fernando Bozza, Carolina B Maciel, David M Greer, Leonardo S L Bastos, Ulisses Melo, Bruno Mazza, Marcelo S Santino and 10 more

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 2 countries.

Pedro KurtzDepartment of Neurointensive Care, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Christian StormDepartment of Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Marcio SoaresDepartment of Intensive Care Medicine, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Fernando BozzaDepartment of Intensive Care Medicine, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Carolina B MacielDepartment of Neurology, University of Florida College of Medicine, Gainesville, FL.
David M GreerDepartment of Neurology, Boston University School of Medicine, Boston, MA.
Leonardo S L BastosDepartment of Industrial Engineering, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil.
Ulisses MeloICU, Hospital Estadual Alberto Torres, São Gonçalo, Brazil.
Bruno MazzaICU, Hospital Samaritano, São Paulo, Brazil.
Marcelo S SantinoICU, Hospital Barra D'Or, Rio de Janeiro, Brazil.
Roberto Seabra LannesICU, Hospital Municipal Souza Aguiar, Rio de Janeiro, Brazil.
Ana Paula Pierre de MoraesICU, Hospital de Câncer do Maranhão Tarquínio Lopes Filho, São Luís, Brazil.
Joel Tavares PassosICU, Hospital Unimed Costa do Sol, Macaé, Brazil.
Giulliana Martines MoralezICU, Hospital Estadual Getúlio Vargas, Rio de Janeiro, Brazil.
Robson Correa SantosICU, Hospital Estadual Adão Pereira Nunes, Duque de Caxias, Brazil.
Maristela Medeiros MachadoICU, Hospital Agenor Paiva, Salvador, Brazil.
Saulo Fernandes SaturninoICU, Department of Emergency, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ciro Leite MendesICU, Hospital Universitário Lauro Wanderley, João Pessoa, Brazil.
Arthur Oswaldo ViannaICU, Clínica São Vicente, Rio de Janeiro, Brazil.
Jorge SalluhDepartment of Intensive Care Medicine, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Instituto Estadual do Cérebro Paulo Niemeyer · BRD’Or Institute for Research and Education · BRPontifical Catholic University of Rio de Janeiro · BRBoston University · USFlorida College · USFundação Getulio Vargas · BRHospital Estadual Centra · BRHospital Samaritano de São Paulo · BRHospital Universitário Lauro Wanderley · BRUniversity of Florida · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectivesData on cardiac arrest survivors from developing countries are scarce. This study investigated clinical characteristics associated with in-hospital mortality in resuscitated patients following cardiac arrest in Brazil.

designRetrospective analysis of prospectively collected data.

settingNinety-two general ICUs from 55 hospitals in Brazil between 2014 and 2015. PATIENTS: Adult patients with cardiac arrest admitted to the ICU.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe analyzed 2,296 patients (53% men; median 67 yr (interquartile range, 54-79 yr]). Eight-hundred patients (35%) had a primary admission diagnosis of cardiac arrest suggesting an out-of-hospital cardiac arrest; the remainder occurred after admission, comprising an in-hospital cardiac arrest cohort. Overall, in-hospital mortality was 83%, with only 6% undergoing withholding/withdrawal-of-life support. Random-effects multivariable Cox regression was used to assess associations with survival. After adjusting for age, sex, and severity scores, mortality was associated with shock (adjusted odds ratio, 1.25 [95% CI, 1.11-1.39];

conclusionsIn a large multicenter cardiac arrest cohort from Brazil, we found a high mortality rate and infrequent withholding/withdrawal of life support. We also identified patient profiles associated with worse survival, such as those with shock/hypoperfusion and arrest secondary to nonsurgical admission diagnoses. Our findings unveil opportunities to improve postarrest care in developing countries, such as prompt ICU admission, expansion of the use of targeted temperature management, and implementation of shock reversal strategies (i.e., early coronary angiography), according to modern guidelines recommendations.

Indexed as

cardiac arrestcritical careheart arrestoutcomes assessmenttargeted temperature managementtherapeutic hypothermia

Identifiers

PMID34345824
PMCPMC8322515
OpenAlexW3182547618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.