ArticleACS central science2021
Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology.
Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Photocatalytic Addition ofOrganic letters · 2025Article
- Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025Review
- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning.Beilstein journal of organic chemistry · 2025Review
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- Structurally Diverse Nitrogen-Rich Scaffolds via Continuous Photo-Click Reactions.Organic letters · 2024Article
- Biogenic metallic nanoparticles: from green synthesis to clinical translation.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- DigiChemTree enables programmable light-induced carbene generation for on demand chemical synthesis.Communications chemistry · 2024Article
- Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.Nature communications · 2024Article
- Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop.JACS Au · 2024Review
- Development of Continuous Additive-Controlled MSMPR Crystallization by DoE-Based Batch Experiments.Industrial & engineering chemistry research · 2024Article
- Synthesis of alcohols: streamlined C1 to CChemical science · 2024Article
- Article
- Improving reproducibility of photocatalytic reactions-how to facilitate broad application of new methods.Nature communications · 2024Article
- A Brief Introduction to Chemical Reaction Optimization.Chemical reviews · 2023Review
- Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines.Organic letters · 2023Article
- Development of a microfluidic photochemical flow reactor concept by rapid prototyping.Frontiers in chemistry · 2023Article
- Zinc-Free, Scalable Reductive Cross-Electrophile Coupling Driven by Electrochemistry in an Undivided Cell.ACS catalysis · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Photoredox catalysis has emerged as a powerful and versatile platform for the synthesis of complex molecules. While photocatalysis is already broadly used in small-scale batch chemistry across the pharmaceutical sector, recent efforts have focused on performing these transformations in process chemistry due to the inherent challenges of batch photocatalysis on scale. However, translating optimized batch conditions to flow setups is challenging, and a general approach that is rapid, convenient, and inexpensive remains largely elusive. Herein, we report the development of a new approach that uses a microscale high-throughput experimentation (HTE) platform to identify optimal reaction conditions that can be directly translated to flow systems. A key design point is to simulate the flow-vessel pathway within a microscale reaction plate, which enables the rapid identification of optimal flow reaction conditions using only a small number of simultaneous experiments. This approach has been validated against a range of widely used photoredox reactions and, importantly, was found to translate accurately to several commercial flow reactors. We expect that the generality and operational efficiency of this new HTE approach to photocatalysis will allow rapid identification of numerous flow protocols for scale.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.