Evidence map›Paper›PMID 34345663›Full record

ReviewACS central science2021

State-of-the-Art Biocatalysis.

Joshua B Pyser, Suman Chakrabarty, Evan O Romero, Alison R H Narayan

Abstract readReview
In one paragraph

Review in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua B PyserDepartment of Chemistry, Life Sciences Institute, and Program in Chemical Biology, University of Michigan, , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0003-2884-5112
Suman ChakrabartyDepartment of Chemistry, Life Sciences Institute, and Program in Chemical Biology, University of Michigan, , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-6611-3839
Evan O RomeroDepartment of Chemistry, Life Sciences Institute, and Program in Chemical Biology, University of Michigan, , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0001-8553-1238
Alison R H NarayanDepartment of Chemistry, Life Sciences Institute, and Program in Chemical Biology, University of Michigan, , 210 Washtenaw Avenue, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0001-8290-0077

Funding

Undergrad Supplement: Expanding the synthetic utility of natural product biosynthetic enzymesR35GM124880 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alison Narayan · 2017 to 2026
$4.5M
NIGMS NIH HHS R35 GM124880
6 · The paper itself

Abstract

The use of enzyme-mediated reactions has transcended ancient food production to the laboratory synthesis of complex molecules. This evolution has been accelerated by developments in sequencing and DNA synthesis technology, bioinformatic and protein engineering tools, and the increasingly interdisciplinary nature of scientific research. Biocatalysis has become an indispensable tool applied in academic and industrial spheres, enabling synthetic strategies that leverage the exquisite selectivity of enzymes to access target molecules. In this Outlook, we outline the technological advances that have led to the field's current state. Integration of biocatalysis into mainstream synthetic chemistry hinges on increased access to well-characterized enzymes and the permeation of biocatalysis into retrosynthetic logic. Ultimately, we anticipate that biocatalysis is poised to enable the synthesis of increasingly complex molecules at new levels of efficiency and throughput.

Identifiers

PMID34345663
PMCPMC8323117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.