Evidence map›Paper›PMID 34345621›Full record

ArticlemHealth2021

mHealth for pre-exposure prophylaxis adherence by young adult men who have sex with men.

Patricia Flynn Weitzman, Yi Zhou, Laura Kogelman, Sarah Rodarte, Sara Romero Vicente, Sue E Levkoff

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mHealth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06072443 (AURORA Study-A Transformative Approach Utilizing Behavioral Economics, Education, and Data Science to Support Patients Initiating PrEP With Retention-in-care and Medication Persistence), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06072443 unknown statusnot on this mapstarted 2023, after this paper: background citation

AURORA Study-A Transformative Approach Utilizing Behavioral Economics, Education, and Data Science to Support Patients Initiating PrEP With Retention-in-care and Medication Persistence

TypeobservationalSponsorWV Health Right, Inc.Ran2023 to 2025Enrolled105ConditionsHIV InfectionsArmsDigital Health Companion (mobile App)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Validation of the PrEP Use Self-Efficacy (PrEP-Use) Scale Among Sexual Minority Men.AIDS education and prevention : official publication of the International Society for AIDS Education · 2025
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  9. The 2025 Centers for Disease Control and Prevention Nonoccupational HIV Postexposure Prophylaxis Guidelines: Updated Regimens and Remaining Questions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patricia Flynn WeitzmanEnvironment and Health Group, Cambridge, MA, USA.
Yi ZhouEnvironment and Health Group, Cambridge, MA, USA.
Laura KogelmanInfectious Disease Clinic, Tufts Medical Center, Boston, MA, USA.
Sarah RodarteEnvironment and Health Group, Cambridge, MA, USA.
Sara Romero VicenteEnvironment and Health Group, Cambridge, MA, USA.
Sue E LevkoffEnvironment and Health Group, Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYoung adult men who have sex with men (YMSM) are at increased risk for HIV, especially minority YMSM. Pre-exposure prophylaxis (PrEP) is a breakthrough daily pill to prevent HIV. Consistent adherence is key to PrEP effectiveness, which is why the CDC recommends adherence support be provided to all PrEP patients. Mobile health can overcome barriers to the delivery of adherence support, particularly for YMSM who may be most in need of it due, at least in part, to their young age.

methodsWe created a culturally- and developmentally-sensitive PrEP adherence mobile app (called "Dot") that was tailored for culturally-diverse young adult MSM. After formative research and usability testing, we conducted a 6-week pre-post study to evaluate the impact of Dot on self-reported PrEP adherence, PrEP treatment self-efficacy, PrEP knowledge, and intention to practice safe sex among culturally-diverse YMSM, age 20-29.

resultsAt 6 weeks, there were significant improvements in PrEP adherence, PrEP self-efficacy, and intention to practice safe sex. PrEP knowledge scores did not significantly change.

conclusionsThe Dot app proved feasible and effective at improving PrEP adherence among culturally-diverse YMSM. Moreover, the app had a high-degree of user appeal, which is foundational to success of an mhealth intervention.

Indexed as

HIVmen who have sex with men (MSM)pre-exposure prophylaxispre-exposure prophylaxis (PrEP)

Identifiers

PMID34345621
PMCPMC8326962

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.