Evidence map›Paper›PMID 34345179›Full record

ArticleJournal of inflammation research2021

Associations of Single Nucleotide Polymorphisms in IL-18 Gene with

Alaa U AlRuwaisan, Mashael R Al-Anazi, Mohammed I Shafeai, Fuad H Rudiny, Ali M Motaen, Saad M Bin Dajem, Hani Alothaid, Kareem Morsy, Saad Alkahtani, Ahmed A Al-Qahtani

Open access · goldAbstract read
In one paragraph

Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Alaa U AlRuwaisanZoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mashael R Al-AnaziDepartment of Infection and Immunity, Research Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Mohammed I ShafeaiSabya General Hospital, Sabya, Saudi Arabia.
Fuad H RudinySabya General Hospital, Sabya, Saudi Arabia.
Ali M MotaenSabya General Hospital, Sabya, Saudi Arabia.
Saad M Bin DajemDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Hani AlothaidDepartment of Basic Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.ORCID 0000-0003-0132-558X
Kareem MorsyDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Saad AlkahtaniZoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0001-7381-5110
Ahmed A Al-QahtaniDepartment of Infection and Immunity, Research Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.ORCID 0000-0003-4584-5739
Hera General Hospital · SAKing Saud University · SAAl Baha University · SAAlfaisal University · SACairo University · EGKing Faisal Specialist Hospital & Research Centre · SAKing Khalid University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInterleukin-18 (IL-18) is a pro-inflammatory cytokine, reported to be involved in the initial immune responses against malaria. Genetic variations in the host are an important factor that influences the etiology of malaria at several disease levels. Polymorphisms within the

methodsWe genotyped single nucleotide polymorphisms (SNPs) in

resultsSNPs rs5744292 (OR = 70.446; 95% CI = 4.318-1149.323; p<0.0001) and rs544354 (OR = 1.498; 95% CI = 1.088-2.063; p=0.013) were found to be significantly associated with parasitemia in

conclusionOur results suggest that polymorphisms within the

Indexed as

IL-18 genePlasmodium falciparumSNPs

Identifiers

PMID34345179
PMCPMC8323861
OpenAlexW3184903001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.