Evidence map›Paper›PMID 34345022›Full record

ReviewNature reviews. Rheumatology2021

Global epidemiology of systemic lupus erythematosus.

Megan R W Barber, Cristina Drenkard, Titilola Falasinnu, Alberta Hoi, Anselm Mak, Nien Yee Kow, Elisabet Svenungsson, Jonna Peterson, Ann E Clarke, Rosalind Ramsey-Goldman

Erratum issued Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07043153 (Using Combination of Albumin to Globulin Ratio and Prognostic Nutritional Index Model for Predicting Disease Activity in Patients With Systemic Lupus Erythematosus), which is not on this map. Cited by 377 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07043153 recruitingnot on this mapstarted 2025, after this paper: background citation

Using Combination of Albumin to Globulin Ratio and Prognostic Nutritional Index Model for Predicting Disease Activity in Patients With Systemic Lupus Erythematosus

TypeobservationalSponsorSohag UniversityRan2025 to 2026Enrolled200ConditionsSystemic Lupus Erythematosus DiseaseArmsAlbumin to globulin ratio and prognostic nutritional index model
3 · Its place in the literature

Who cites it

377 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  10. Guideline
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317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Megan R W BarberDivision of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0003-1055-1335
Cristina DrenkardDepartment of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6832-7291
Titilola FalasinnuDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford School of Medicine, Stanford, CA, USA.
Alberta HoiSchool of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9416-7383
Anselm MakDivision of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4688-7829
Nien Yee KowDivision of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-5492-3172
Elisabet SvenungssonDepartment of Medicine Solna, Unit of Rheumatology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3396-3244
Jonna PetersonGalter Health Sciences Library and Learning Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-6585-892X
Ann E ClarkeDivision of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-3112-9646
Rosalind Ramsey-GoldmanDepartment of Medicine, Rheumatology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. rgramsey@northwestern.edu.ORCID http://orcid.org/0000-0001-8712-787X

Funding

Characterization of Chronic Pain and its Biopsychosocial Mechanisms in Lupus using Electronic Health RecordsK01AR079039 · NIAMS · STANFORD UNIVERSITY · PI FALASINNU, TITILOLA · 2021 to 2025
$631k
NIAMS NIH HHS K01 AR079039
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations that predominantly affects young women. Certain ethnic groups are more vulnerable than others to developing SLE and experience increased morbidity and mortality. Reports of the global incidence and prevalence of SLE vary widely, owing to inherent variation in population demographics, environmental exposures and socioeconomic factors. Differences in study design and case definitions also contribute to inconsistent reporting. Very little is known about the incidence of SLE in Africa and Australasia. Identifying and remediating such gaps in epidemiology is critical to understanding the global burden of SLE and improving patient outcomes. Mortality from SLE is still two to three times higher than that of the general population. Internationally, the frequent causes of death for patients with SLE include infection and cardiovascular disease. Even without new therapies, mortality can potentially be mitigated with enhanced quality of care. This Review focuses primarily on the past 5 years of global epidemiological studies and discusses the regional incidence and prevalence of SLE and top causes of mortality.

Indexed as

AfricaAsiaAustralasiaEuropeGlobal HealthHumansIncidenceLupus Erythematosus, SystemicPrevalenceSouth America

Identifiers

PMID34345022
PMCPMC8982275

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.