Evidence map›Paper›PMID 34344965›Full record

ArticleScientific reports2021

Pre-screening for osteoporosis with calcaneus quantitative ultrasound and dual-energy X-ray absorptiometry bone density.

Chia-Chi Yen, Wei-Chun Lin, Tzu-Hao Wang, Guan-Fan Chen, Da-Ying Chou, Dian-Min Lin, Shu-Yuan Lin, Min-Ho Chan, Jia-Ming Wu, Chin-Dar Tseng and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Osteoporosis: current diagnostic possibilities, a literature review.Przeglad menopauzalny = Menopause review · 2026
    Review
  6. Article
  7. Current Uses for Medical Imaging With Orthopaedic Implant Technology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Review
  8. Development of Artificial Intelligence-Assisted Lumbar and Femoral BMD Estimation System Using Anteroposterior Lumbar X-Ray Images.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chia-Chi YenDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Wei-Chun LinDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan. patrdrwc@gmail.com.
Tzu-Hao WangDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Guan-Fan ChenDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Da-Ying ChouDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Dian-Min LinDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Shu-Yuan LinDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Min-Ho ChanDepartment of Orthopedic, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
Jia-Ming WuDepartment of Biomedicine Engineering, Chengde Medical University, Chengde, 067000, Hebei, China.
Chin-Dar TsengMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, ROC.
Yu-Jie HuangDepartment of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83342, Taiwan, ROC.
Tsair-Fwu LeeMedical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, ROC. tflee@nkust.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcaneal quantitative ultrasonography (QUS) is a useful prescreening tool for osteoporosis, while the dual-energy X-ray absorptiometry (DXA) is the mainstream in clinical practice. We evaluated the correlation between QUS and DXA in a Taiwanese population. A total of 772 patients were enrolled and demographic data were recorded with the QUS and DXA T-score over the hip and spine. The correlation coefficient of QUS with the DXA-hip was 0.171. For DXA-spine, it was 0.135 overall, 0.237 in females, and 0.255 in males. The logistic regression model using DXA-spine as a dependent variable was established, and the classification table showed 66.2% accuracy. A receiver operating characteristic (ROC) analyses with Youden's Index revealed the optimal cut-off point of QUS for predicting osteoporosis to be 2.72. This study showed a meaningful correlation between QUS and DXA in a Taiwanese population. Thus, it is important to pre-screen for osteoporosis with calcaneus QUS.

Indexed as

Bone DensityAbsorptiometry, PhotonAgedAged, 80 and overCalcaneusFemaleHumansLogistic ModelsMaleMass ScreeningMiddle AgedOsteoporosisPrognosisROC CurveSensitivity and SpecificityTaiwan

Identifiers

PMID34344965
PMCPMC8333105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.