ArticleScientific reports2021
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence on microplastic exposure and respiratory health outcomes: a systematic review.Therapeutic advances in respiratory diseasePooled it
- Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism.Nature metabolism · 2026Article
- Article
- Inhaled Micro- and Nanoplastics as Environmental Modifiers of Lung Carcinogenesis: Mechanistic Insights and Evidence Synthesis.Journal of xenobiotics · 2026Review
- Fucoidan-Functionalized Nanoparticles for Antimycobacterial Therapy: A Promising Approach against Drug-ResistantACS omega · 2026Article
- Spatial transcriptome mapping identifiesScience advances · 2026Article
- The Particle Size Effect: Cytotoxicity and Cellular Uptake of Polystyrene Nanoplastics in Human Keratinocytes.Toxics · 2026Article
- Apical-out airway organoids as a pathophysiological model to study macrophage-mediated epithelial responses to microplastics.Materials today. Bio · 2026Article
- Rapid single-live-cell scanningMethodsX · 2026Article
- Effect of Starch Microparticles on the Activation and Bactericidal Activity of Murine Alveolar Macrophages Infected withMicroorganisms · 2026Article
- Impact of nanoplastics emitted from incineration of polyethylene plastic on THP-1 macrophage viability and immune function.Journal of hazardous materials · 2026Article
- Gut microbiota dysbiosis exacerbates polystyrene microplastics-induced liver inflammation via activating LPS/TLR4 signaling pathway in ducks.Poultry science · 2025Article
- Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro-Inflammatory Macrophage Activation.Advanced healthcare materials · 2025Article
- Biological Effects of Micro-/Nano-Plastics in Macrophages.Nanomaterials (Basel, Switzerland) · 2025Review
- Top-down generated micro- and nanoplastics reduce macrophage viability without eliciting a pro-inflammatory response.Microplastics and nanoplastics · 2025Article
- Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions.World journal of gastroenterology · 2024Article
- Nominally identical microplastic models differ greatly in their particle-cell interactions.Nature communications · 2024Article
- Detection and specific chemical identification of submillimeter plastic fragments in complex matrices such as compost.Scientific reports · 2024Article
- Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging.The Science of the total environment · 2023Article
- Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs.NanoImpact · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastic (MP) contamination has been identified as an ecological problem with an increasing impact on everyday life. Yet, possible effects of MP at the cellular level are still poorly understood. Here, the interaction of murine macrophages (J774A.1, ImKC) and epithelial cells (STC-1, BNL CL.2) with well-characterized poly(styrene) MP particles (MPP) of varying sizes (0.2-6.0 µm) was studied. Macrophages are expected to actively engulf particles which could be confirmed in this study, while epithelial cells are found in tissues with direct contact with ingested or inhaled MPP. Here, the epithelial cells from both investigated cell lines did not ingest MPP in significant numbers. Concomitantly, no cytotoxic effects nor any influence on cellular proliferation were observed. Cells from the two macrophage cell lines showed high ingestion of MPP of all sizes, but cytotoxic effects were observed only for one of them (ImKC) and only at MPP concentrations above 250 µg/mL. Indications of cellular stress as well as effects on cell proliferation were observed for cell populations with high particle cell interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.