Evidence map›Paper›PMID 34344871›Full record

ArticleNature communications2021

Time-varying optimization of COVID-19 vaccine prioritization in the context of limited vaccination capacity.

Shasha Han, Jun Cai, Juan Yang, Juanjuan Zhang, Qianhui Wu, Wen Zheng, Huilin Shi, Marco Ajelli, Xiao-Hua Zhou, Hongjie Yu

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Optimizing infectious disease mitigation under dynamic conditions.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shasha Han *Beijing International Center for Mathematical Research, Peking University, Beijing, China.ORCID 0000-0001-7388-8125
Jun Cai *School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.ORCID 0000-0001-9495-1226
Juan YangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.ORCID 0000-0001-5028-2227
Juanjuan ZhangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Qianhui WuSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Wen ZhengSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Huilin ShiSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Marco AjelliDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN, USA.ORCID 0000-0003-1753-4749
Xiao-Hua ZhouBeijing International Center for Mathematical Research, Peking University, Beijing, China. azhou@math.pku.edu.cn.ORCID 0000-0001-7935-1222
Hongjie YuSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. yhj@fudan.edu.cn.ORCID 0000-0002-6335-5648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamically adapting the allocation of COVID-19 vaccines to the evolving epidemiological situation could be key to reduce COVID-19 burden. Here we developed a data-driven mechanistic model of SARS-CoV-2 transmission to explore optimal vaccine prioritization strategies in China. We found that a time-varying vaccination program (i.e., allocating vaccines to different target groups as the epidemic evolves) can be highly beneficial as it is capable of simultaneously achieving different objectives (e.g., minimizing the number of deaths and of infections). Our findings suggest that boosting the vaccination capacity up to 2.5 million first doses per day (0.17% rollout speed) or higher could greatly reduce COVID-19 burden, should a new wave start to unfold in China with reproduction number ≤1.5. The highest priority categories are consistent under a broad range of assumptions. Finally, a high vaccination capacity in the early phase of the vaccination campaign is key to achieve large gains of strategic prioritizations.

Indexed as

Basic Reproduction NumberChinaCOVID-19COVID-19 VaccinesHealth Care RationingHealth PrioritiesHumansIncidenceMass VaccinationModels, TheoreticalSARS-CoV-2Vaccination CoverageCOVID-19 Vaccines

Identifiers

PMID34344871
PMCPMC8333090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.