Bilateral Renal Hypoplasia with High β2-Microglobulinuria in the Neonatal Period.

Sadayuki Nagai, Kazumichi Fujioka, Shogo Minamikawa, Kandai Nozu, Kazumoto Iijima

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Article in The Kobe journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors at 1 institution in 1 country.

Sadayuki NagaiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Kazumichi FujiokaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Shogo MinamikawaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Kandai NozuDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Kazumoto IijimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary β2 microglobulin (β2-MG) is a low-molecular-weight protein that is filtered by the glomerular basement membrane and absorbed by the proximal tubule epithelial cells. In perinatal management, urinary β2-MG levels are used to assess intrauterine inflammation in newborns, since urinary excretion increases during inflammation. Furthermore, β2-MG levels in fetal blood and urine are also used for predicting fetal renal function because β2-MG is not transferred to the placenta. Herein, we reported a patient with persistent high urinary β2-MG levels since neonatal period, who was later diagnosed with bilateral renal hypoplasia. If a newborn presents persistent hyper β2-microglobulinuria even without hematuria or proteinuria, congenital renal malformations should be considered.

Indexed as

InflammationUltrasonographybeta 2-MicroglobulinHumansInfant, NewbornKidneybeta 2-MicroglobulinNeonateRenal hypoplasiaUrinary β2-microglobulin

Identifiers

PMID34344855

PMCPMC8622258

OpenAlexW3189406175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.