Evidence map›Paper›PMID 34344789›Full record

ArticleDiabetes2021

Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes.

Diane Yang, Sanjeet Patel, Wojciech J Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam and 1 more

Erratum issuedOpen access · bronzeAbstract readCase Reports
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Treatment Options for Patients with Maturity-Onset Diabetes of the Young (MODY): A Systematic Review of Literature: 2026 Update.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Diane YangCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX.
Sanjeet PatelDivision of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Wojciech J SzlachcicAdam Mickiewicz University, Poznan, Poland.
Jolanta ChmielowiecCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX.
Diane ScadutoHealthLabs.com, Houston, TX.
Nagireddy PutluriCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX.
Arun SreekumarCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX.
James SuliburkDepartment of Surgery, Baylor College of Medicine, Houston, TX.
Michael MetzkerRedVault Biosciences, Houston, TX.
Ashok BalasubramanyamDivision of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX ashokb@bcm.edu malbor3@amu.edu.pl.ORCID 0000-0003-2093-5201
Malgorzata BorowiakCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX ashokb@bcm.edu malbor3@amu.edu.pl.
Houston Methodist · USBaylor College of Medicine · USAdam Mickiewicz University in Poznań · PLThe University of Texas Health Science Center at Houston · USUniversity of Southern California · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Diabetes Endocrinology Research CenterP30DK079638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 2008 to 2012
$6.4M
NCI NIH HHS P30 CA125123NIDDK NIH HHS P30 DK079638
6 · The paper itself

Abstract

Genetic analysis of an adult patient with an unusual course of ketosis-prone diabetes (KPD) and lacking islet autoantibodies demonstrated a nucleotide variant in the 5'-untranslated region (UTR) of

Indexed as

AdultCell DifferentiationCells, CulturedDiabetes Mellitus, Type 1DNA Mutational AnalysisGene Expression RegulationHomeodomain ProteinsHumansInduced Pluripotent Stem CellsInsulin-Secreting CellsMalePancreasSyndromeTrans-ActivatorsHomeodomain Proteinspancreatic and duodenal homeobox 1 proteinTrans-Activators

Identifiers

PMID34344789
PMCPMC8576504
OpenAlexW3188775673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.