Evidence map›Paper›PMID 34344786›Full record

ArticleGut2022

Suppressor CD4

Wafa Khamri, Cathrin Gudd, Tong Liu, Rooshi Nathwani, Marigona Krasniqi, Sofia Azam, Thomas Barbera, Francesca M Trovato, Lucia Possamai, Evangelos Triantafyllou and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Mechanisms of immunity in acutely decompensated cirrhosis and acute-on-chronic liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Wafa KhamriSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK w.khamri@imperial.ac.uk.ORCID 0000-0001-9101-8457
Cathrin GuddSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Tong LiuSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Rooshi NathwaniSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.ORCID 0000-0002-5069-7956
Marigona KrasniqiSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Sofia AzamSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Thomas BarberaSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Francesca M TrovatoDepartment of Inflammation Biology, Institute of Liver Studies, King's College London, London, UK.
Lucia PossamaiSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Evangelos TriantafyllouSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.ORCID 0000-0002-2755-9619
Rocio Castro SeoaneSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Fanny LebosseSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Arjuna SinganayagamSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Naveenta KumarSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Christine BernsmeierSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Sujit MukherjeeSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Mark McPhailDepartment of Inflammation Biology, Institute of Liver Studies, King's College London, London, UK.ORCID 0000-0001-5449-2424
Chris J WestonNIHR Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, UK.
Charalambos Gustav AntoniadesSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Mark R ThurszSection of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Imperial College London · GBKing's College London · GBNIHR Birmingham Liver Biomedical Research Unit · GB

Funding

Medical Research Council MR/K010514/1Medical Research Council MR/R014019/1
6 · The paper itself

Abstract

objectiveIdentifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4

designFlow cytometry was used to determine the proportion and immunophenotype of CD4

resultsPatients with AD were distinguished by an expansion of a CD4

conclusionWe have identified a cytokine-driven peripherally derived suppressive population that may contribute to immuneparesis in AD.

Indexed as

HLA-G AntigensT-Lymphocyte SubsetsCD4-Positive T-LymphocytesCytokinesHumansInterleukinsLiver CirrhosisCytokinesHLA-G AntigensInterleukinsimmunology in hepatologyimmunoregulation

Identifiers

PMID34344786
PMCPMC9120410
OpenAlexW3188217036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.