Evidence map›Paper›PMID 34344721›Full record

SynthesisOpen heart2021

Heart failure in pregnancy: what is the long-term impact of pregnancy on cardiac function? A tertiary care centre experience and systematic review.

Anudeep K Dodeja, Francesca Siegel, Katherine Dodd, Marwan Ma'ayeh, Laxmi S Mehta, Margaret M Fuchs, Kara M Rood, May Ling Mah, Elisa A Bradley

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anudeep K DodejaDivision of Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA anujassal@gmail.com.ORCID 0000-0003-4462-3114
Francesca SiegelThe Ohio State University College of Medicine, Columbus, Ohio, USA.
Katherine DoddDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.
Marwan Ma'ayehDepartment of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH, USA.
Laxmi S MehtaDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.
Margaret M FuchsMayo Clinic Division of Cardiovascular Diseases, Rochester, Minnesota, USA.ORCID 0000-0002-6820-5681
Kara M RoodDepartment of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH, USA.
May Ling MahDivision of Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Elisa A BradleyDepartment of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-1479-2988
The Ohio State University · USNationwide Children's Hospital · USMayo Clinic · US

Funding

Defining New Pathways for Complex Human Heart Failure and ArrhythmiaK08HL148701 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BRADLEY, ELISA ANN · 2020 to 2024
$805k
NHLBI NIH HHS K08 HL148701
6 · The paper itself

Abstract

backgroundWomen with cardiomyopathy (CM) are often advised against pregnancy due to risk for major adverse cardiovascular events (MACE). However, the impact of CM subtype on maternal MACE is not understood, and so we sought to evaluate the influence of CM phenotype on maternal outcomes, as well as the effect on immediate and late left ventricular function.

methodsWe evaluated all pregnant women in our high-risk maternal cardiovascular programme (2009-2019). Composite maternal MACE included: death, inotrope use, left ventricular assist device, orthotopic heart transplant and/or escalation in transplant listing status, acute decompensated heart failure and sustained ventricular arrhythmia.

resultsAmong 875 women followed, 32 had CM (29±7 years old, left ventricular ejection fraction (LVEF) 41%±12%): 3 ischaemic CM (ICM), 10 peripartum CM (PPCM) and 19 non-ICM (NICM). MACE events occurred in 6 (18%) women (PPCM: 2 (33%), NICM: 4 (67%)). There was no difference in LVEF at baseline, however, women with MACE had significantly lower LVEF both early (LVEF: 27±5% vs . 41±2%, p<0.05) and late post partum (LVEF: 28±5% vs . 44±2%, p<0.01).

conclusionsIn this contemporary cohort of women with CM, maternal MACE rates were lower than previously reported, and were less common in PPCM as compared with ICM and NICM. Heart function in women with MACE was negatively impacted immediately after delivery and in late postpartum follow-up, suggesting that pregnancy itself likely has influence on future left ventricular function in women with underlying CM.

Indexed as

EchocardiographyFemaleGlobal HealthHeart FailureHeart VentriclesHumansMagnetic Resonance Imaging, CineMorbidityPeripartum PeriodPostpartum PeriodPregnancyPregnancy Complications, CardiovascularPregnancy OutcomeRisk FactorsStroke VolumeTertiary Care Centersheart failuremyocardial diseasepregnancy

Identifiers

PMID34344721
PMCPMC8336161
OpenAlexW3187543461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.