Evidence map›Paper›PMID 34344668›Full record

ArticleBMJ global health2021

Prevalence and determinants of inappropriate antibiotic dispensing at private drug retail outlets in urban and rural areas of Indonesia: a mixed methods study.

Luh Putu Lila Wulandari, Mishal Khan, Marco Liverani, Astri Ferdiana, Yusuf Ari Mashuri, Ari Probandari, Tri Wibawa, Neha Batura, Gill Schierhout, John Kaldor and 8 more

Abstract read
In one paragraph

Article in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Phylogenetic analysisOpen veterinary journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Luh Putu Lila WulandariThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-3397-3648
Mishal KhanDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-8967-1761
Marco LiveraniDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-0829-291X
Astri FerdianaCenter for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0003-0666-4302
Yusuf Ari MashuriCenter for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0002-3494-9842
Ari ProbandariCenter for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0003-3171-5271
Tri WibawaCenter for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0003-0477-4575
Neha BaturaInstitute for Global Health, University College London, London, UK.ORCID 0000-0002-8175-8125
Gill SchierhoutThe George Institute for Global Health, UNSW Sydney, Newtown, New South Wales, Australia.ORCID 0000-0002-6399-7624
John KaldorThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-7639-4355
Rebecca GuyThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-2929-4634
Matthew LawThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-3540-8837
Richard DaySt Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-6045-6937
Johanna HanefeldDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-9487-2333
Harry ParathonAntibiotic Resistance Control Committee, Indonesian Ministry of Health, Jakarta, Indonesia.
Stephen JanThe George Institute for Global Health, UNSW Sydney, Newtown, New South Wales, Australia.ORCID 0000-0003-2839-1405
Shunmay YeungDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-0997-0850
Virginia WisemanThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia virginia.wiseman@lshtm.ac.uk.ORCID 0000-0002-7911-0741

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this mixed-method study was to determine the extent and determinants of inappropriate dispensing of antibiotics by licensed private drug retail outlets in Indonesia.

methodsStandardised patients (SPs) made a total of 495 visits to 166 drug outlets (community pharmacies and drug stores) between July and August 2019. The SPs presented three clinical cases to drug outlet staff: parent of a child at home with diarrhoea; an adult with presumptive tuberculosis (TB); and an adult with upper respiratory tract infection (URTI). The primary outcome was the dispensing of an antibiotic without prescription, with or without the client requesting it. We used multivariable random effects logistic regression to assess factors associated with the primary outcome and conducted 31 interviews with drug outlet staff to explore these factors in greater depth.

resultsAntibiotic dispensing without prescription occurred in 69% of SP visits. Dispensing antibiotics without a prescription was more likely in standalone pharmacies and pharmacies attached to clinics compared with drug stores, with an OR of 5.9 (95% CI 3.2 to 10.8) and OR of 2.2 (95% CI 1.2 to 3.9); and more likely for TB and URTI SP-performed cases compared with child diarrhoea cases, with an OR of 5.7 (95% CI 3.1 to 10.8) and OR of 5.2 (95% CI 2.7 to 9.8). Interviews revealed that inappropriate antibiotic dispensing was driven by strong patient demand for antibiotics, unqualified drug sellers dispensing medicines, competition between different types of drug outlets, drug outlet owners pushing their staff to sell medicines, and weak enforcement of regulations.

conclusionThis study shows that inappropriate dispensing of antibiotics by private drug retail outlets is widespread. Interventions will need to address not only the role of drug sellers, but also the demand for antibiotics among clients and the push from drug outlet owners to compete with other outlets.

Indexed as

Pharmaceutical PreparationsPharmaciesAdultAnti-Bacterial AgentsChildHumansIndonesiaPrevalenceAnti-Bacterial AgentsPharmaceutical Preparationscross-sectional surveyhealth services researchhealth systems evaluationpublic healthqualitative study

Identifiers

PMID34344668
PMCPMC8336216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.