Evidence map›Paper›PMID 34344651›Full record

ArticleBMJ case reports2021

Effective use of monoclonal antibodies for treatment of persistent COVID-19 infection in a patient on rituximab.

Carlos X Rabascall, Becky X Lou, Brianne Navetta-Modrov, Stella S Hahn

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Potency of Xanthone Derivatives fromMolecules (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Severe relapse of SARS-CoV-2 infection in a kidney transplant recipient with negative nasopharyngeal SARS-CoV-2 RT-PCR after rituximab.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  9. Review
  10. Article
  11. Persistent COVID and a Return to Sport.Current sports medicine reports · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos X RabascallPulmonary, Critical Care and Sleep Medicine, Northwell Health, New Hyde Park, New York, USA crabascallay@northwell.edu.
Becky X LouPulmonary, Critical Care and Sleep Medicine, Northwell Health, New Hyde Park, New York, USA.
Brianne Navetta-ModrovRheumatology, Allergy and Immunology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Stella S HahnPulmonary, Critical Care and Sleep Medicine, Northwell Health, New Hyde Park, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As we are over a year into the COVID-19 pandemic, we have made many forward strides in therapeutics. These treatments, such as monoclonal antibodies, have help mitigate the detrimental and often fatal consequences of COVID-19. The current indication for the use of monoclonal antibodies is mild to moderate COVID-19 infection within 10 days of symptom onset in those who are at high risk of progression to severe disease. However, their role in patients with prolonged symptoms is not clear. We present a unique case of monoclonal antibodies use after 54 days of symptom onset in an immunosuppressed patient with persistent COVID-19 infection despite standard treatment. This case illustrates the potential use of monoclonal antibodies outside of the current recommended therapeutic window in immunosuppressed patients, who may have difficulty with viral clearance.

Indexed as

COVID-19Antibodies, MonoclonalHumansPandemicsRituximabSARS-CoV-2Antibodies, MonoclonalRituximabCOVID-19drugs: respiratory systempneumonia (respiratory medicine)

Identifiers

PMID34344651
PMCPMC8336168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.