Evidence map›Paper›PMID 34344539›Full record

ArticleThe International journal on drug policy2021

Machine learning takes a village: Assessing neighbourhood-level vulnerability for an overdose and infectious disease outbreak.

Jesse L Yedinak, Yu Li, Maxwell S Krieger, Katharine Howe, Colleen Daley Ndoye, Hyunjoon Lee, Anna M Civitarese, Theodore Marak, Elana Nelson, Elizabeth A Samuels and 3 more

Abstract read
In one paragraph

Article in The International journal on drug policy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Urban spatial risk prediction and optimization analysis of POI based on deep learning from the perspective of an epidemic.International journal of applied earth observation and geoinformation : ITC journal · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jesse L YedinakDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Yu LiDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Maxwell S KriegerDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Katharine HoweCenter for HIV, Hepatitis, STD, and TB Epidemiology, Rhode Island Department of Health, Providence, RI, USA.
Colleen Daley NdoyeProject Weber/Renew: Harm Reduction & Recovery Services Provider, Providence, RI, USA.
Hyunjoon LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Anna M CivitareseCenter for HIV, Hepatitis, STD, and TB Epidemiology, Rhode Island Department of Health, Providence, RI, USA.
Theodore MarakCenter for HIV, Hepatitis, STD, and TB Epidemiology, Rhode Island Department of Health, Providence, RI, USA.
Elana NelsonDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Elizabeth A SamuelsDepartment of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA; Overdose Prevention Program, Rhode Island Department of Health, Providence, RI, USA.
Philip A ChanDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA; Center for HIV, Hepatitis, STD, and TB Epidemiology, Rhode Island Department of Health, Providence, RI, USA.
Thomas BertrandCenter for HIV, Hepatitis, STD, and TB Epidemiology, Rhode Island Department of Health, Providence, RI, USA.
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: brandon_marshall@brown.edu.

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI Ju Nyeong Park · 2018 to 2026
$23.4M
NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

backgroundMultiple areas in the United States of America (USA) are experiencing high rates of overdose and outbreaks of bloodborne infections, including HIV and hepatitis C virus (HCV), due to non-sterile injection drug use. We aimed to identify neighbourhoods at increased vulnerability for overdose and infectious disease outbreaks in Rhode Island, USA. The primary aim was to pilot machine learning methods to identify which neighbourhood-level factors were important for creating "vulnerability assessment scores" across the state. The secondary aim was to engage stakeholders to pilot an interactive mapping tool and visualize the results.

methodsFrom September 2018 to November 2019, we conducted a neighbourhood-level vulnerability assessment and stakeholder engagement process named The VILLAGE Project (Vulnerability Investigation of underlying Local risk And Geographic Events). We developed a predictive analytics model using machine learning methods (LASSO, Elastic Net, and RIDGE) to identify areas with increased vulnerability to an outbreak of overdose, HIV and HCV, using census tract-level counts of overdose deaths as a proxy for injection drug use patterns and related health outcomes. Stakeholders reviewed mapping tools for face validity and community distribution.

resultsMachine learning prediction models were suitable for estimating relative neighbourhood-level vulnerability to an outbreak. Variables of importance in the model included housing cost burden, prior overdose deaths, housing density, and education level. Eighty-nine census tracts (37%) with no prior overdose fatalities were identified as being vulnerable to such an outbreak, and nine of those were identified as having a vulnerability assessment score in the top 25%. Results were disseminated as a vulnerability stratification map and an online interactive mapping tool.

conclusionMachine learning methods are well suited to predict neighborhoods at higher vulnerability to an outbreak. These methods show promise as a tool to assess structural vulnerabilities and work to prevent outbreaks at the local level.

Indexed as

Drug OverdoseSubstance Abuse, IntravenousDisease OutbreaksHumansMachine LearningRisk FactorsUnited Stateshepatitis CHIVMachine learningNeighbourhoodOverdosePredictive analyticsStructural vulnerability

Identifiers

PMID34344539
PMCPMC8568646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.