SynthesisActa neuropathologica communications2021
Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review.
Synthesis in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Comparing the value of dynamic versus static image-based tests of emotion recognition in neurodegenerative disease.Journal of neuropsychology · 2026Article
- Language impairments in behavioural variant frontotemporal dementia: a comparative study with semantic dementia.Journal of neurology · 2026Article
- Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD.Journal of neurology · 2026Article
- TBK1-Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia.Annals of clinical and translational neurology · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group.Communications medicine · 2025Review
- Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants.European journal of neurology · 2025Article
- Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Modelling pathological spread through the structural connectome in the frontotemporal dementia clinical spectrum.Brain : a journal of neurology · 2025Article
- Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer's disease: a longitudinal study.Journal of neurology · 2025Article
- Primary Progressive Aphasias: Diagnosis and Treatment.Brain sciences · 2025Review
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Clinical, Cortical, Subcortical, and White Matter Features of Right Temporal Variant FTD.Brain sciences · 2024Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Hemispheric asymmetries in hippocampal volume related to memory in left and right temporal variants of frontotemporal degeneration.Frontiers in neurology · 2024Article
- A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy.Acta neuropathologica communications · 2023Article
- Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023Review
- Frontotemporal Degeneration with Transactive Response DNA-Binding Protein Type C at the Anterior Temporal Lobe.Annals of neurology · 2023Review
- Temporopolar regions of the human brain.Brain : a journal of neurology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying histopathology remains elusive. Being considered a right-sided variant of semantic variant primary progressive aphasia (svPPA), TDP-43 type C pathology has been linked to the syndrome, but this has not been studied in detail in large cohorts. In this case report and systematic review, we report the autopsy results of five subjects diagnosed with rtvFTD from our cohort and 44 single rtvFTD subjects from the literature. Macroscopic pathological evaluation of the combined results revealed that rtvFTD demonstrated either a frontotemporal or temporal evolution, even if the degeneration started in the right temporal lobe initially. FTLD-TDP type C was the most common underlying pathology in rtvFTD, however, in 64% of rtvFTD, other underlying pathologies than FTLD-TDP type C were present, such as Tau-MAPT and FTLD-TDP type A and B. Additionally, accompanying motor neuron or corticospinal tract degeneration was observed in 28% of rtvFTD patients. Our results show that in contrast to the general assumption, rtvFTD might not be a pure FTLD-TDP type C disorder, unlike its left temporal counterpart svPPA. Large sample size pathological studies are warranted to understand the diverse pathologies of the right and left temporal variants of frontotemporal dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.