Evidence map›Paper›PMID 34344420›Full record

ArticleOrphanet journal of rare diseases2021

Retrospective study on growth in infants with isolated Robin sequence treated with the Tuebingen Palate Plate.

Cornelia Wiechers, Regina Iffländer, Rieke Gerdes, Melissa Ciuffolotti, Jörg Arand, Christina Weise, Katharina Peters, Bärbel Grandke, Siegmar Reinert, Bernd Koos and 1 more

Open access · goldAbstract read
In one paragraph

Article in Orphanet journal of rare diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Speech Outcomes in Children with Robin Sequence Treated with a Pre-Epiglottic Baton Plate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Palatal plates for treating infants with Robin sequence.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  9. Diagnosis and Early Management of Robin Sequence.Children (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Cornelia WiechersDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany.
Regina IffländerDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany.
Rieke GerdesDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany.
Melissa CiuffolottiDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany.
Jörg ArandDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany.
Christina WeiseInterdisciplinary Center for Craniofacial Malformations, Speech Therapy Centre, Tuebingen University Hospital, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Katharina PetersInterdisciplinary Center for Craniofacial Malformations, Speech Therapy Centre, Tuebingen University Hospital, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Bärbel GrandkeInterdisciplinary Center for Craniofacial Malformations, Speech Therapy Centre, Tuebingen University Hospital, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Siegmar ReinertInterdisciplinary Center for Craniofacial Malformations, Speech Therapy Centre, Tuebingen University Hospital, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Bernd KoosInterdisciplinary Center for Craniofacial Malformations, Speech Therapy Centre, Tuebingen University Hospital, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.
Christian F PoetsDepartment of Neonatology, Tuebingen University Hospital, Calwerstraße 7, 72076, Tuebingen, Germany. Christian-f.poets@med.uni-tuebingen.de.ORCID 0000-0002-1072-0066
STZ eyetrial · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with Robin sequence (RS) are at risk of growth failure, mainly due to their increased work of breathing and feeding difficulties. Various conservative and surgical treatment approaches exist, but their impact on weight gain has not yet been adequately addressed. A functional treatment concept, used in our center for > 20 years, includes a pre-epiglottic baton plate (Tuebingen palatal plate) and intensive feeding training.

objectiveTo investigate the effect of the Tuebingen treatment protocol on growth and weight trajectories during infancy.

methodsThis retrospective study analyzed longitudinal data from infants with isolated RS admitted to Tuebingen University Children's Hospital, Germany between 1998 and 2019. Through our electronic patient database, we evaluated anthropometric parameters until reaching 1-year follow-up. Results are shown as median (IQR).

resultsIn 307 infants analyzed, median Z-score for weight decreased from - 0.28 at birth to - 1.12 upon admission to our center at a median age of 22 days. Z-score then remained largely unchanged until discharge (Z-score difference, - 0.08), while the proportion of infants receiving tube feedings decreased from 55.1 to 13.7%. Z-score subsequently increased from - 1.17 at discharge to - 0.44 at the 1-year follow-up (p < 0.001).

conclusionBased on a comparatively large cohort, this functional treatment was associated with better weight gain and improved feeding. As RS infants often show postnatal growth failure, weight monitoring may be a valuable parameter for monitoring treatment effectiveness. Clinical Trial Registration Not necessary due to the retrospective design.

Indexed as

Pierre Robin SyndromeChildHospitalizationHumansInfantInfant, NewbornPalateRetrospective StudiesTreatment OutcomeFeeding difficultiesGrowthInfantNutritionPierre RobinPre-epiglottic baton plateRobin sequence

Identifiers

PMID34344420
PMCPMC8335857
OpenAlexW3188114377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.