Trial reportRadiation oncology (London, England)2021
Personalising treatment plan quality review with knowledge-based planning in the TROG 15.03 trial for stereotactic ablative body radiotherapy in primary kidney cancer.
Trial report in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Version upgrades in treatment planning Systems affect clinical application of a multi-Centre knowledge-based planning model.Technical innovations & patient support in radiation oncology · 2026Article
- Systematic comparison of manual, knowledge-based, and feasibility DVH approaches for prostate VMAT: stability and robustness.Physical and engineering sciences in medicine · 2026Article
- A multi-institutional dummy run on segmentation variability and plan quality of stereotactic body radiotherapy for oligometastatic disease.Physics and imaging in radiation oncology · 2025Article
- Auto-Segmentation and Auto-Planning in Automated Radiotherapy for Prostate Cancer.Bioengineering (Basel, Switzerland) · 2025Article
- Critical assessment of knowledge-based models for craniospinal irradiation of paediatric patients.Physics and imaging in radiation oncology · 2025Article
- Online adaptive planning methods for intensity-modulated radiotherapy.Physics in medicine and biology · 2023Review
- Article
- Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data.Physics and imaging in radiation oncology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionQuality assurance (QA) of treatment plans in clinical trials improves protocol compliance and patient outcomes. Retrospective use of knowledge-based-planning (KBP) in clinical trials has demonstrated improved treatment plan quality and consistency. We report the results of prospective use of KBP for real-time QA of treatment plan quality in the TROG 15.03 FASTRACK II trial, which evaluates efficacy of stereotactic ablative body radiotherapy (SABR) for kidney cancer.
methodsA KBP model was generated based on single institution data. For each patient in the KBP phase (open to the last 31 patients in the trial), the treating centre submitted treatment plans 7 days prior to treatment. A treatment plan was created by using the KBP model, which was compared with the submitted plan for each organ-at-risk (OAR) dose constraint. A report comparing each plan for each OAR constraint was provided to the submitting centre within 24 h of receiving the plan. The centre could then modify the plan based on the KBP report, or continue with the existing plan.
resultsReal-time feedback using KBP was provided in 24/31 cases. Consistent plan quality was in general achieved between KBP and the submitted plan. KBP review resulted in replan and improvement of OAR dosimetry in two patients. All centres indicated that the feedback was a useful QA check of their treatment plan.
conclusionKBP for real-time treatment plan review was feasible for 24/31 cases, and demonstrated ability to improve treatment plan quality in two cases. Challenges include integration of KBP feedback into clinical timelines, interpretation of KBP results with respect to clinical trade-offs, and determination of appropriate plan quality improvement criteria.
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