Evidence map›Paper›PMID 34344313›Full record

ArticleBMC gastroenterology2021

Genotype-phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients.

Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl, Isabelle Frey-Wagner and 1 more

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In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Priyatharsan YoganathanDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Jean-Benoit RosselCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Sebastian Bruno Ulrich JordiDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Yannick FrancCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Luc BiedermannDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Benjamin MisselwitzDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Martin HausmannDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Gerhard RoglerDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Michael ScharlDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
Isabelle Frey-WagnerDepartment of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland. isabelle.frey@access.uzh.ch.ORCID http://orcid.org/0000-0002-0125-3072
Swiss IBD cohort study group
University of Zurich · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 3347CO-108792
6 · The paper itself

Abstract

backgroundGenetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn's Disease (CD). NLRP3 is part of the NLRP3-inflammasome that mediates the maturation of IL-1β and IL-18. Carrying the major allele of the single nucleotide polymorphisms (SNPs) rs10733113, rs4353135 and rs55646866 is associated with an increased risk for CD. We here studied the impact of these polymorphisms on clinical characteristics in patients of the Swiss IBD Cohort Study (SIBDCS).

methodsWe included 981 Crohn's disease (CD) patients and 690 ulcerative colitis (UC) patients of the SIBDCS. We analyzed whether three CD-associated NLRP3 polymorphisms have an impact on the clinical disease course in these patients.

resultsIn CD patients presence of the major allele (G) of rs10733113 was associated with less surgeries and lower maximal CDAI and a similar trend was observed for rs55646866 and rs4353135. Presence of the major allele of all three SNPs was negatively correlated to maximal CDAI. In UC patients homozygous genotype for the major allele (CC) for rs55646866 was associated with a higher age at diagnosis and a higher MTWAI index. Homozygous genotype for the major allele of all three polymorphisms was associated with a higher number of ambulatory visits and longer hospital stays.

conclusionsIn CD patients presence of the major allele of all three polymorphisms was associated with markers of a less severe disease course, while in UC the homozygous genotype for all major alleles suggested a more severe disease activity.

Indexed as

Colitis, UlcerativeInflammatory Bowel DiseasesCohort StudiesGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansNLR Family, Pyrin Domain-Containing 3 ProteinNLR ProteinsPolymorphism, Single NucleotidePyrin DomainSwitzerlandNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNLR ProteinsClinical characteristicsInflammatory bowel diseaseNLRP3 inflammasomeSingle nucleotide polymorphisms

Identifiers

PMID34344313
PMCPMC8336111
OpenAlexW3187921033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.