ArticleBMC infectious diseases2021
Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Trends of adenovirus occurrence in drinking and wastewater treatment plants of the city of Hamadan, Iran.Journal of water and health · 2025Article
- Characterization of Human Viral Diversity and Adenovirus Isolates in a Sewage Treatment Plant in Tianjin: Implications for Public Health and Advanced Monitoring.Food and environmental virology · 2025Article
- Epidemiological characteristics of human adenovirus infections in China, 2020-2023.Biosafety and health · 2025Article
- Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China.Frontiers in cellular and infection microbiology · 2025Article
- Molecular characterization of human adenoviruses associated with pediatric respiratory infections in Karachi, Pakistan.BMC infectious diseases · 2024Article
- Genetic Diversity of the Human Adenovirus C Isolated from Hospitalized Children in Russia (2019-2022).Viruses · 2024Article
- Higher affinities of fibers with cell receptors increase the infection capacity and virulence of human adenovirus type 7 and type 55 compared to type 3.Microbiology spectrum · 2024Article
- Genotypes and Phylogenetic Analysis of Human Adenovirus in Hospitalized Pneumonia and Influenza-Like Illness Patients in Jiangsu Province, China (2013-2021).Infection and drug resistance · 2024Article
- Molecular epidemiology and characteristics of respiratory syncytial virus among hospitalized children in Guangzhou, China.Virology journal · 2023Article
- Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases.PLoS neglected tropical diseases · 2023Article
- Molecular characterisation of human adenoviruses associated with respiratory infections in Uganda.BMC infectious diseases · 2023Article
- Generation and Characterization of a Replication-Competent Human Adenovirus Type 55 Encoding EGFP.Viruses · 2023Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs).
methodsTo understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes.
resultsHAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer.
conclusionAll ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.
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