Evidence map›Paper›PMID 34344041›Full record

ArticleAmerican journal of perinatology2023

Association of Surgical Necrotizing Enterocolitis and Its Timing with Retinopathy of Prematurity.

Jennifer B Fundora, Gil Binenbaum, Lauren Tomlinson, Yinxi Yu, Gui-Shuang Ying, Akhil Maheshwari, Pamela Donohue

Abstract read
In one paragraph

Article in American journal of perinatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. The characteristics of racial disparity in retinopathy of prematurity outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  10. Article
  11. The impact of gut microbiota on morbidities in preterm infants.The Kaohsiung journal of medical sciences · 2024
    Review
  12. Article
  13. Observational
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer B FundoraDivision of Neonatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3531-0239
Gil BinenbaumDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Lauren TomlinsonDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Yinxi YuDepartment of Ophthalmology, Center for Preventative Ophthalmology and Biostatistics, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Gui-Shuang YingDepartment of Ophthalmology, Center for Preventative Ophthalmology and Biostatistics, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Akhil MaheshwariGlobal Newborn Society, Baltimore, Maryland.
Pamela DonohueDivision of Neonatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Postnatal Growth and Retinopathy of Prematurity (G-ROP) StudiesR01EY021137 · NEI · CHILDREN'S HOSP OF PHILADELPHIA · PI BINENBAUM, GIL · 2012 to 2016
$4.3M
Institutional Training for PediatriciansT32HD044355 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BRADY, TAMMY MCLOUGHLIN · 2003 to 2023
$4.1M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
Secondary Analysis of Data from G-ROP StudyR21EY029776 · NEI · UNIVERSITY OF PENNSYLVANIA · PI YING, GUI-SHUANG · 2019 to 2020
$471k
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY021137NEI NIH HHS R21 EY029776NHLBI NIH HHS R01 HL124078NHLBI NIH HHS R01 HL133022NICHD NIH HHS T32 HD044355
6 · The paper itself

Abstract

objectiveThe study aimed to determine the association of surgical necrotizing enterocolitis (NEC) and its timing, with the development and timing of retinopathy of prematurity (ROP). STUDY

designThis was a secondary data analysis of 7,483 preterm infants from the Postnatal Growth and Retinopathy of Prematurity Study. Associations between infants with surgical NEC, early-onset surgical NEC (8-28 days), and late-onset surgical NEC (over 28 days) with ROP were evaluated by using multivariable logistic regression models, controlling for birth weight, gestational age, small for gestational age status, chronic lung disease, intraventricular hemorrhage, hydrocephalus, patent ductus arteriosus, and periventricular leukomalacia.

resultsThree hundred fifty-six (4.8%) infants had surgical NEC, with 56% having early surgical NEC. Infants with surgical NEC had a higher risk of any ROP and severe ROP (adjusted odds ratio [OR]: 2.7; 95% CI: 1.9-3.7) and 2.5 (95% CI: 1.9-3.3), respectively;

conclusionInfants with surgical NEC, especially early surgical NEC, are at higher risk of ROP and severe ROP. KEY POINTS: · Infants with surgical NEC are at higher risk of ROP and severe ROP than those without surgical NEC.. · Increased ROP risk is seen in infants with both early- or later onset surgical NEC.. · Early-onset surgical NEC is associated with a higher ROP risk compared with later onset surgical NEC..

Indexed as

Enterocolitis, NecrotizingRetinopathy of PrematurityFemaleGestational AgeHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, Premature

Identifiers

PMID34344041
PMCPMC8939240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.