Evidence map›Paper›PMID 34343858›Full record

ArticleBiomaterials2021

Neutrophils aid cellular therapeutics by enhancing glycoengineered stem cell recruitment and retention at sites of inflammation.

Arezoo Momeni, Lisa Eagler, Chi Y Lo, Brian R Weil, John M Canty, Jennifer K Lang, Sriram Neelamegham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Glycoengineering in antigen-specific immunotherapies.Current opinion in chemical biology · 2024
    Review
  5. E-selectin in vascular pathophysiology.Frontiers in immunology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arezoo MomeniDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: arezoomo@buffalo.edu.
Lisa EaglerDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Veterans Affairs Western New York Health Care System, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: lavathy@buffalo.edu.
Chi Y LoDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: lochiying@gmail.com.
Brian R WeilDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: bweil@buffalo.edu.
John M CantyDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Veterans Affairs Western New York Health Care System, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: canty@buffalo.edu.
Jennifer K LangDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Veterans Affairs Western New York Health Care System, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Pharmacology and Toxicology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: jklang@buffalo.edu.
Sriram NeelameghamDivision of Cardiovascular Medicine and the Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: neel@buffalo.edu.
University at Buffalo, State University of New York · USVA Western New York Healthcare System · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Systems Biology of GlycosylationR01HL103411 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2011 to 2025
$7.1M
IVIS Spectrum Imaging SystemS10OD016450 · OD · ROSWELL PARK CANCER INSTITUTE CORP · PI SPERNYAK, JOSEPH ANDREW · 2013 to 2013
$406k
Preventing and Reversing Interstitial Fibrosis in HFpEFI01BX002659 · VA · VA WESTERN NEW YORK HEALTHCARE SYSTEM · PI Brian Raymond Weil · 2016 to 2026
–
The Functional Role of Exosomes in Stem Cell Mediated Cardiac RepairIK2BX004097 · VA · VA WESTERN NEW YORK HEALTHCARE SYSTEM · PI LANG, JENNIFER K · 2019 to 2024
–
BLRD VA I01 BX002659BLRD VA IK2 BX004097NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NHLBI NIH HHS R01 HL103411NIH HHS S10 OD016450
6 · The paper itself

Abstract

The efficacy of cell-based therapies relies on targeted payload delivery and enhanced cell retention. In vitro and in vivo studies suggest that the glycoengineering of mesenchymal and cardiosphere-derived cells (CDCs) may enhance such recruitment at sites of injury. We evaluated the role of blood cells in amplifying this recruitment. Thus, the human α(1,3)fucosyltransferase FUT7 was stably expressed in CDCs, sometimes with P-selectin glycoprotein ligand-1 (PSGL-1/CD162). Such FUT7 over-expression resulted in cell-surface sialyl Lewis-X (sLe

Indexed as

Endothelial CellsNeutrophilsAnimalsCell AdhesionInflammationMiceP-SelectinStem CellsP-SelectinCell adhesionCell therapyFluid shearGlycoengineeringSelectinSialyl Lewis-X

Identifiers

PMID34343858
PMCPMC9533316
OpenAlexW3185184849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.