Evidence map›Paper›PMID 34343850›Full record

ArticleHearing research2021

Interaction of micropatterned topographical and biochemical cues to direct neurite growth from spiral ganglion neurons.

Kristy Truong, Braden Leigh, Joseph T Vecchi, Reid Bartholomew, Linjing Xu, C Allan Guymon, Marlan R Hansen

Open access · bronzeAbstract read
In one paragraph

Article in Hearing research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kristy TruongDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, United States.
Braden LeighDepartment of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242, United States.
Joseph T VecchiDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, United States.
Reid BartholomewDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, United States.
Linjing XuDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, United States.
C Allan GuymonDepartment of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242, United States.
Marlan R HansenDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, United States; Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, United States. Electronic address: marlan-hansen@uiowa.edu.
University of Iowa · US

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
Reduction of Intracochlear Trauma and Fibrosis Using Dual Network, Zwitterionic Hydrogel Thin Films on Cochlear Implant SurfacesR01DC012578 · NIDCD · UNIVERSITY OF IOWA · PI Allan Guymon, Marlan R Hansen · 2013 to 2026
$6.3M
Research Training Program in OtolaryngologyT32DC000040 · NIDCD · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R · 1993 to 2025
$5.4M
University of Iowa Institute for Clinical and Translational ScienceU54TR001013 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2014 to 2014
$4.2M
NCATS NIH HHS U54 TR001013NCATS NIH HHS UL1 TR002537NIDCD NIH HHS R01 DC012578NIDCD NIH HHS T32 DC000040NIGMS NIH HHS T32 GM007337NIGMS NIH HHS T32 GM139776
6 · The paper itself

Abstract

Functional outcomes with neural prosthetic devices, such as cochlear implants, are limited in part due to physical separation between the stimulating elements and the neurons they stimulate. One strategy to close this gap aims to precisely guide neurite regeneration to position the neurites in closer proximity to electrode arrays. Here, we explore the ability of micropatterned biochemical and topographic guidance cues, singly and in combination, to direct the growth of spiral ganglion neuron (SGN) neurites, the neurons targeted by cochlear implants. Photopolymerization of methacrylate monomers was used to form unidirectional topographical features of ridges and grooves in addition to multidirectional patterns with 90

Indexed as

NeuritesSpiral GanglionCells, CulturedCuesNeuronsPolymersPolymersNeurite growthNeurite guidancePathfindingRegenerative medicineSpiral ganglion neurons

Identifiers

PMID34343850
PMCPMC8419132
OpenAlexW3185002350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.