ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023
Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical Overconnectivity.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 41 citations in OpenAlex.
- Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats.Molecular psychiatry · 2026Article
- Excitation/Inhibition Balance as a Mechanistic Link Between Sleep Disturbance and Autism Spectrum Disorder: A Bidirectional Framework.Alpha psychiatry · 2026Review
- Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.Molecular psychiatry · 2026Review
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- Latent Profile Analysis of Sleep Patterns in Children With Autism Spectrum Disorder.Pediatric discovery · 2026Article
- The spectrum of neurodevelopmental disorders: comorbidities as clues to pathogenesis.Current opinion in psychiatry · 2026Review
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Linking auditory brain responses to cortical microstructure and sensory behaviors in autism spectrum disorder: a preliminary study.Frontiers in psychiatry · 2026Article
- Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism.Journal of neurodevelopmental disorders · 2025Article
- Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.European journal of pediatrics · 2025Observational
- Sleep problems and sensory features in children with low-average cognitive abilities and autism spectrum disorder.Scientific reports · 2025Article
- PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice.Journal of nanobiotechnology · 2025Article
- Abnormalities in brain complexity in children with autism spectrum disorder: a sleeping state functional MRI study.BMC psychiatry · 2025Article
- Differences in sleep EEG coherence and spindle metrics in toddlers with and without receptive/expressive language delay: a prospective observational study.Journal of neurodevelopmental disorders · 2025Observational
- Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism.Molecular autism · 2025Article
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- Lipidomics Analysis Reveals the Effects of Docosahexaenoic Acid from Different Sources on Prefrontal-Cortex Synaptic Plasticity.Nutrients · 2025Article
- Atypical Neural Responses to Native and Non-Native Language in Infants at High Likelihood for Developing Autism.Research square · 2024Article
- How auditory processing influences the autistic profile: A review.Autism research : official journal of the International Society for Autism Research · 2024Review
- Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing.Autism research : official journal of the International Society for Autism Research · 2024Article
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10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProjections between the thalamus and sensory cortices are established early in development and play an important role in regulating sleep as well as in relaying sensory information to the cortex. Atypical thalamocortical functional connectivity frequently observed in children with autism spectrum disorder (ASD) might therefore be linked to sensory and sleep problems common in ASD.
methodsHere, we investigated the relationship between auditory-thalamic functional connectivity measured during natural sleep functional magnetic resonance imaging, sleep problems, and sound sensitivities in 70 toddlers and preschoolers (1.5-5 years old) with ASD compared with a matched group of 46 typically developing children.
resultsIn children with ASD, sleep problems and sensory sensitivities were positively correlated, and increased sleep latency was associated with overconnectivity between the thalamus and auditory cortex in a subsample with high-quality magnetic resonance imaging data (n = 29). In addition, auditory cortex blood oxygen level-dependent signal amplitude was elevated in children with ASD, potentially reflecting reduced sensory gating or a lack of auditory habituation during natural sleep.
conclusionsThese findings indicate that atypical thalamocortical functional connectivity can be detected early in development and may play a crucial role in sleep problems and sensory sensitivities in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.